Document Detail

Oxygen dependency of life-span in the nematode.
MedLine Citation:
PMID:  8102956     Owner:  NLM     Status:  MEDLINE    
1. The mean and maximum life-spans of both wild type Caenorhabditis elegans and the mev-1(kn1) mutant, whose cytoplasmic superoxide dismutase activity level is about half of the wild type, were increased and decreased under low and high concentrations of oxygen, respectively. 2. The Gompertz component, a parameter of ageing rate, of the wild type was smaller under 1% oxygen than under 2% or more oxygen. Further, the Gompertz component of the mutant increased with an increase in oxygen concentration. 3. The oxygen-dependent modulation of life-span and ageing rate seems to be enhanced by a genetic defect of the mutant in antioxidant defence.
M Matsuo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. Comparative physiology     Volume:  105     ISSN:  -     ISO Abbreviation:  Comp. Biochem. Physiol. Comp. Physiol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-30     Completed Date:  1993-09-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9441449     Medline TA:  Comp Biochem Physiol Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  653-8     Citation Subset:  IM    
Tokyo Metropolitan Institute of Gerontology, Japan.
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MeSH Terms
Caenorhabditis elegans / enzymology,  physiology*
Life Expectancy
Oxygen / physiology*
Superoxide Dismutase / metabolism
Reg. No./Substance:
7782-44-7/Oxygen; EC Dismutase

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