Document Detail

Oxygen delivery-consumption relationship in adult respiratory distress syndrome patients: the effects of sepsis.
MedLine Citation:
PMID:  8343858     Owner:  NLM     Status:  MEDLINE    
The oxygen consumption-delivery relationship (VO2/DO2) was studied in 15 sedated paralyzed patients with the adult respiratory distress syndrome (ARDS) due to multiple trauma and in whom sepsis was absent. Different levels (0 to 15 cm H2O) of positive end-expiratory pressure (PEEP) were applied. Oxygen delivery was calculated from cardiac index (thermodilution technique) and arterial oxygen content measurements. Oxygen consumption was calculated using Fick's equation. Regression lines were obtained for each patient. Oxygen supply dependency was defined as a significant (P < .05) relationship between changes in VO2 and DO2 with PEEP. Results were compared with those obtained in 18 ARDS patients in whom ARDS was due to sepsis. In nonseptic ARDS patients no significant relationship between changes in VO2 and DO2 with PEEP was found within the experimental range of DO2 on zero end-expiratory pressure (ZEEP) (347 to 845 mL/min/m2). None of these patients had multiple organ system failure (MOSF), and 73% survived. In ARDS patients in whom sepsis was present, supply dependency was present only when DO2 on ZEEP ranged between 330 and 640 mL/min/m2. All these patients developed MOSF and died. When DO2 on ZEEP ranged between 686 and 951 mL/min/m2 in septic ARDS patients, the supply dependency phenomenon was absent and only three patients developed MOSF and died (70% survivors). In almost all patients PEEP reduced DO2 and therefore worsened O2 balance by either increasing O2 extraction ratio and approaching the critical threshold for supply dependency or dismissing DO2 from the range of non-supply dependency.
A Spec-Marn; L Tos; B Kremzar; J Milic-Emili; V M Ranieri
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of critical care     Volume:  8     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-09-08     Completed Date:  1993-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Institute of Anesthesia, University of Ljubliana, Republic of Slovenia.
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MeSH Terms
Cardiac Volume
Middle Aged
Multiple Organ Failure / physiopathology
Oxygen / pharmacokinetics*
Oxygen Consumption*
Positive-Pressure Respiration
Respiratory Distress Syndrome, Adult / physiopathology*,  therapy
Sepsis / physiopathology
Reg. No./Substance:

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