Document Detail


Oxygen consumption in sepsis and septic shock.
MedLine Citation:
PMID:  2026029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review article examines the pathophysiology of septic shock, with special attention to the concept of supply-dependent consumption and the implications this concept has for therapy. Patients with septic shock require higher levels of oxygen delivery (DO2) to maintain aerobic metabolism. When DO2 is inadequate, peripheral tissues switch to anaerobic metabolism and oxygen consumption decreases. The lactic acidosis that occurs is a reasonable clinical marker of supply dependency and inadequate tissue perfusion. Maximizing DO2 is an important part of the hemodynamic resuscitation of patients with septic shock. To achieve this goal, intravascular volume must be restored and the myocardial depression associated with sepsis must be treated to optimize cardiac output. The normalization of arterial lactate concentration is a reasonable goal of resuscitative efforts.
Authors:
J Tuchschmidt; D Oblitas; J C Fried
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care medicine     Volume:  19     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  664-71     Citation Subset:  AIM; IM    
Affiliation:
Division of Pulmonary Disease and Critical Care Medicine, University of Southern California, School of Medicine, Los Angeles.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Infections / metabolism*,  physiopathology,  therapy
Hemodynamics
Humans
Oxygen Consumption*
Shock, Septic / metabolism*,  physiopathology,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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