Document Detail


Oxygen consumption during maximal exercise in Fischer 344 x Brown Norway F1 hybrid rats.
MedLine Citation:
PMID:  15345729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We characterized O2 consumption (VO2) during treadmill exercise in 12-, 24-, and 35-month-old Fischer 344 x Brown Norway F1 hybrid (F344BNF1) rats. When accounting for differences in body mass (Mb), (O2)peak decreased by 10% and 33% in 24- and 35-month-old rats, respectively, compared with rats at 12 months (analysis of covariance, p < .01). O2 cost per unit work at VO2peak (i.e., VO2peak/work) was greater in 35-month-old rats compared with 12- and 24-month-old rats (p < .001). During submaximal exercise, the O2 cost was greater in 24- and 35-month-old than 12-month-old rats (p < .01). Analysis of covariance revealed similar patterns irrespective of differences in Mb or lean Mb as covariates. The underlying mechanism responsible for increasing O2 consumption in aged F344BNF1 rats during exercise, although partly explained by mechanical inefficiencies of locomotion, still remains to be determined.
Authors:
I Mark Olfert; Jamal Balouch; Odile Mathieu-Costello
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  59     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-03     Completed Date:  2004-10-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  801-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2004 The Gerontological Society of America
Affiliation:
Department of Medicine, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0623, USA. molfert@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Oxygen Consumption / physiology*
Physical Conditioning, Animal / physiology*
Rats
Rats, Inbred BN
Rats, Inbred F344
Grant Support
ID/Acronym/Agency:
HL07212/HL/NHLBI NIH HHS; HL17731/HL/NHLBI NIH HHS; M01 RR00827/RR/NCRR NIH HHS

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