Document Detail

Oxygen consumption and coronary reactivity in postischemic myocardium.
MedLine Citation:
PMID:  2909305     Owner:  NLM     Status:  MEDLINE    
Coronary vascular responses in regions of reversible postischemic myocardial contractile dysfunction (stunned myocardium) were examined in chronically instrumented, awake dogs. Left anterior descending coronary artery blood flow and oxygen extraction, aortic and left ventricular pressures, and regional myocardial segment shortening were determined. Regional myocardial blood flow was measured with microspheres. Coronary reactive hyperemia and vasodilator reserve, and regional myocardial oxygen consumption were determined. Three sequential 10-minute left anterior descending coronary artery occlusions separated by 30-minute reperfusion periods resulted in progressive postischemic dysfunction so that 1 hour after the final coronary artery occlusion, myocardial segment shortening was reduced to 37% of baseline. Despite this decrease in contractile function, left anterior descending artery flow (19.6 +/- 2.6 vs. 18.4 +/- 3.0 ml/min), myocardial blood flow and the transmural distribution of flow measured with microspheres, and regional myocardial oxygen consumption were unchanged. Although the coronary vasodilator reserve in response to adenosine was unaltered (63 +/- 9 vs. 70 +/- 15 ml/min), the reactive hyperemia response to a 10-second coronary occlusion was decreased in intensity (debt repayment ratio = 474 +/- 78% vs. 322 +/- 74%; p less than 0.05) and duration (57 +/- 9.1 vs. 35 +/- 4.5 seconds; p less than 0.05), while the peak flow response was unchanged (57 +/- 6.8 vs. 60 +/- 7.1 ml/min). Thus, in the intact awake animal postischemic myocardial contractile dysfunction was not associated with decreased myocardial oxygen consumption and did not impair the normal relation between coronary blood flow and myocardial oxygen utilization. Although coronary vessels showed a normal ability to vasodilate in response to adenosine, coronary reactive hyperemia was reduced.
D D Laxson; D C Homans; X Z Dai; E Sublett; R J Bache
Related Documents :
20061545 - Preoxygenated hemoglobin-based oxygen carrier hboc-201 annihilates myocardial ischemia ...
1929625 - Inotropic stimulation and oxygen consumption in a canine model of dilated cardiomyopathy.
7453225 - Extending the limits of hemodilution on cardiopulmonary bypass using stroma-free hemogl...
937355 - Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynami...
21760805 - Atrial septal defects presenting initially in adulthood: patterns of clinical presentat...
9165155 - Angioscopy variables predictive of early angiographic outcome after excimer laser-assis...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  64     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-20     Citation Subset:  IM    
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Circulation
Coronary Vessels / physiopathology*
Heart / physiopathology
Hyperemia / physiopathology
Myocardial Reperfusion Injury / metabolism,  physiopathology*
Myocardium / metabolism
Oxygen Consumption*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  "Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, ...
Next Document:  Risk of right bundle-branch block and complete heart block during pulmonary artery catheterization.