| Oxygen consumption and biosynthetic function in perfused liver from rats at different stages of development. | |
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MedLine Citation:
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PMID: 9849619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in mitochondrial function were studied in perfused liver from rats aged 24-365 days. Oxygen consumption together with the rates of gluconeogenesis, urea synthesis and ketogenesis were determined. Basal mitochondrial respiration as well as the ability of the liver to synthesize glucose, urea and ketone bodies declined from 24- to 365-day-old rats. On the other hand, on transition from 24 to 60 days the liver oxidation rate of hexanoate, sorbitol and glycerol is enhanced, but not of ketone bodies or palmitate. Our results show that the transition from weaning to middle age is accompanied by defined changes in hepatic substrate oxidation. From the observed time course of the decrease in basal and substrate-stimulated oxygen consumption, it is concluded that in rat liver cells a decline in respiratory chain function, long-chain fatty acid and ketone body metabolism, gluconeogenesis and ureogenesis occurs at a relatively early life stage. |
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Authors:
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M P Mollica; S Iossa; G Liverini; S Soboll |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 54 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-08 Completed Date: 1999-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 1277-82 Citation Subset: IM |
Affiliation:
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Department of General and Environmental Physiology, University of Naples Federico II, Napoli, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Gluconeogenesis / physiology Glycerol / metabolism Hexanoic Acids / metabolism Ketones / metabolism Liver / growth & development, metabolism* Male Mitochondria, Liver / metabolism Oxygen Consumption Palmitates / metabolism Perfusion Rats Rats, Wistar Sorbitol / metabolism Urea / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hexanoic Acids; 0/Ketones; 0/Palmitates; 142-62-1/hexanoic acid; 50-70-4/Sorbitol; 56-81-5/Glycerol; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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