Document Detail

Oxygen consumption after cardiopulmonary bypass surgery in children: determinants and implications.
MedLine Citation:
PMID:  10694613     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to assess oxygen consumption and its determinants in children shortly after undergoing cardiopulmonary bypass operations. METHODS: Twenty children, aged 2 months to 15 years (median, 3.75 years), undergoing hypothermic cardiopulmonary bypass operations were studied during the first 4 hours after arrival in the intensive care unit. Central and peripheral temperatures were monitored. Oxygen consumption was continuously measured by using respiratory mass spectrometry. Oxygen delivery was calculated from oxygen consumption and arterial and mixed venous oxygen contents, which were sampled every 30 minutes. Oxygen extraction was derived by the ratio of oxygen consumption and oxygen delivery. Arterial blood lactate levels were measured every 30 minutes. RESULTS: There was a correlation between oxygen consumption and age in patients older than 3 months (r = -0.76). Mean oxygen consumption increased by 14.7% during the study. The increase in oxygen consumption was correlated with the increase in central temperature (r = 0.73). Nine patients had an arterial lactate level above 2 mmol/L on arrival. There were no significant differences in oxygen consumption, oxygen delivery, and oxygen extraction between the group with lactate levels between 2 and 3 mmol/L and the groups with normal lactate levels both on arrival and at 2 hours. One patient with a peak lactate level of 6.8 mmol/L had initially low oxygen delivery (241.3 mL. min(-1). m(-2)). CONCLUSIONS: During the early hours after a pediatric cardiac operation, the increase in oxygen consumption is mainly attributed to the increase in central temperature. Oxygen consumption is negatively related to age. Mild lactatemia is common and does not appear to reflect oxygen delivery or oxygen consumption or a more complicated recovery.
J Li; I Schulze-Neick; C Lincoln; D Shore; M Scallan; A Bush; A N Redington; D J Penny
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  119     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-13     Completed Date:  2000-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-33     Citation Subset:  AIM; IM    
Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
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MeSH Terms
Age Factors
Body Temperature
Cardiopulmonary Bypass*
Child, Preschool
Lactates / blood
Oxygen Consumption*
Postoperative Period
Time Factors
Reg. No./Substance:
Comment In:
J Thorac Cardiovasc Surg. 2001 Apr;121(4):816-7   [PMID:  11279428 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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