| Oxygen consumption after cardiopulmonary bypass surgery in children: determinants and implications. | |
| | |
MedLine Citation:
|
PMID: 10694613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We sought to assess oxygen consumption and its determinants in children shortly after undergoing cardiopulmonary bypass operations. METHODS: Twenty children, aged 2 months to 15 years (median, 3.75 years), undergoing hypothermic cardiopulmonary bypass operations were studied during the first 4 hours after arrival in the intensive care unit. Central and peripheral temperatures were monitored. Oxygen consumption was continuously measured by using respiratory mass spectrometry. Oxygen delivery was calculated from oxygen consumption and arterial and mixed venous oxygen contents, which were sampled every 30 minutes. Oxygen extraction was derived by the ratio of oxygen consumption and oxygen delivery. Arterial blood lactate levels were measured every 30 minutes. RESULTS: There was a correlation between oxygen consumption and age in patients older than 3 months (r = -0.76). Mean oxygen consumption increased by 14.7% during the study. The increase in oxygen consumption was correlated with the increase in central temperature (r = 0.73). Nine patients had an arterial lactate level above 2 mmol/L on arrival. There were no significant differences in oxygen consumption, oxygen delivery, and oxygen extraction between the group with lactate levels between 2 and 3 mmol/L and the groups with normal lactate levels both on arrival and at 2 hours. One patient with a peak lactate level of 6.8 mmol/L had initially low oxygen delivery (241.3 mL. min(-1). m(-2)). CONCLUSIONS: During the early hours after a pediatric cardiac operation, the increase in oxygen consumption is mainly attributed to the increase in central temperature. Oxygen consumption is negatively related to age. Mild lactatemia is common and does not appear to reflect oxygen delivery or oxygen consumption or a more complicated recovery. |
| | |
Authors:
|
J Li; I Schulze-Neick; C Lincoln; D Shore; M Scallan; A Bush; A N Redington; D J Penny |
Related Documents
:
|
15705053 - Effects of electrical muscle stimulation on oxygen consumption. 9241693 - Effects on pulmonary function of daily exposure to dry or humidified hyperbaric oxygen. 16238853 - Adherence to an exercise prescription scheme: the role of expectations, self-efficacy, ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of thoracic and cardiovascular surgery Volume: 119 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-04-13 Completed Date: 2000-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 525-33 Citation Subset: AIM; IM |
Affiliation:
|
Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Age Factors Body Temperature Cardiopulmonary Bypass* Child Child, Preschool Female Humans Lactates / blood Male Oxygen Consumption* Postoperative Period Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Lactates |
| Comments/Corrections | |
Comment In:
|
J Thorac Cardiovasc Surg. 2001 Apr;121(4):816-7
[PMID:
11279428
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children...
Next Document: Vascular endothelial growth factor and basic fibroblast growth factor in children with cyanotic cong...