Document Detail

Oxygen concentration and characteristics of progressive atelectasis formation during anaesthesia.
MedLine Citation:
PMID:  21039356     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: atelectasis is a common consequence of pre-oxygenation with 100% oxygen during induction of anaesthesia. Lowering the oxygen level during pre-oxygenation reduces atelectasis. Whether this effect is maintained during anaesthesia is unknown.
METHODS: during and after pre-oxygenation and induction of anaesthesia with 60%, 80% or 100% oxygen concentration, followed by anaesthesia with mechanical ventilation with 40% oxygen in nitrogen and positive end-expiratory pressure of 3 cmH(2) O, we used repeated computed tomography (CT) to investigate the early (0-14 min) vs. the later time course (14-45 min) of atelectasis formation.
RESULTS: in the early time course, atelectasis was studied awake, 4, 7 and 14 min after start of pre-oxygenation with 60%, 80% or 100% oxygen concentration. The differences in the area of atelectasis formation between awake and 7 min and between 7 and 14 min were significant, irrespective of oxygen concentration (P<0.05). During the late time course, studied after pre-oxygenation with 80% oxygen, the differences in the area of atelectasis formation between awake and 14 min, between 14 and 21 min, between 21 and 28 min and finally between 21 and 45 min were all significant (P<0.05).
CONCLUSION: formation of atelectasis after pre-oxygenation and induction of anaesthesia is oxygen and time dependent. The benefit of using 80% oxygen during induction of anaesthesia in order to reduce atelectasis diminished gradually with time.
L Edmark; U Auner; M Enlund; E Ostberg; G Hedenstierna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-29
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  55     ISSN:  1399-6576     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-03-17     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Copyright Information:
2010 The Acta Anaesthesiologica Scandinavica Foundation.
Departments of Anaesthesiology and Intensive Care Radiology, Central Hospital, Västerås, Sweden.
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MeSH Terms
Anesthesia / adverse effects*
Intraoperative Complications / chemically induced*,  metabolism*
Lung / radiography
Middle Aged
Models, Statistical
Oxygen / administration & dosage*,  adverse effects*
Oxygen Consumption / physiology*
Positive-Pressure Respiration
Pulmonary Atelectasis / chemically induced*,  radiography
Respiration, Artificial
Tomography, X-Ray Computed
Reg. No./Substance:
Erratum In:
Acta Anaesthesiol Scand. 2011 Jul;55(6):766

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