| Oxygen concentration and characteristics of progressive atelectasis formation during anaesthesia. | |
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MedLine Citation:
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PMID: 21039356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: atelectasis is a common consequence of pre-oxygenation with 100% oxygen during induction of anaesthesia. Lowering the oxygen level during pre-oxygenation reduces atelectasis. Whether this effect is maintained during anaesthesia is unknown. METHODS: during and after pre-oxygenation and induction of anaesthesia with 60%, 80% or 100% oxygen concentration, followed by anaesthesia with mechanical ventilation with 40% oxygen in nitrogen and positive end-expiratory pressure of 3 cmH(2) O, we used repeated computed tomography (CT) to investigate the early (0-14 min) vs. the later time course (14-45 min) of atelectasis formation. RESULTS: in the early time course, atelectasis was studied awake, 4, 7 and 14 min after start of pre-oxygenation with 60%, 80% or 100% oxygen concentration. The differences in the area of atelectasis formation between awake and 7 min and between 7 and 14 min were significant, irrespective of oxygen concentration (P<0.05). During the late time course, studied after pre-oxygenation with 80% oxygen, the differences in the area of atelectasis formation between awake and 14 min, between 14 and 21 min, between 21 and 28 min and finally between 21 and 45 min were all significant (P<0.05). CONCLUSION: formation of atelectasis after pre-oxygenation and induction of anaesthesia is oxygen and time dependent. The benefit of using 80% oxygen during induction of anaesthesia in order to reduce atelectasis diminished gradually with time. |
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Authors:
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L Edmark; U Auner; M Enlund; E Ostberg; G Hedenstierna |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-29 |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 55 ISSN: 1399-6576 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-03 Completed Date: 2011-03-17 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM |
Copyright Information:
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2010 The Acta Anaesthesiologica Scandinavica Foundation. |
Affiliation:
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Departments of Anaesthesiology and Intensive Care Radiology, Central Hospital, Västerås, Sweden. lennart.edmark@ltv.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia / adverse effects* Female Humans Hysterectomy Intraoperative Complications / chemically induced*, metabolism* Lung / radiography Middle Aged Models, Statistical Oxygen / administration & dosage*, adverse effects* Oxygen Consumption / physiology* Positive-Pressure Respiration Pulmonary Atelectasis / chemically induced*, radiography Respiration, Artificial Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Acta Anaesthesiol Scand. 2011 Jul;55(6):766 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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