Document Detail

Oxygen and carbon dioxide in the regulation of respiration.
MedLine Citation:
PMID:  14849     Owner:  NLM     Status:  MEDLINE    
When a sea-level resident ascends to a high altitude, his breathing immediately increases because of hypoxic stimulation of the peripheral chemoreceptors. In many species the aortic bodies are relatively unimportant in this response compared to the carotid bodies. When the subject stays at that altitude, his breathing increases progressively in the next few hours and days in a process termed ventilatory acclimatization and does not immediately return to control levels when hypoxia is terminated. Evidence is summarized indicating that this chronic process does not depend on the peripheral chemoreceptors or an initial respiratory alkalosis. Historical review indicates that the process of ventilatory acclimatization was initially attributed to renal excretion of plasma bicarbonate with development of a metabolic acidosis; but subsequent measurements indicated this process did not lower the arterial pH sufficiently to account for the ventilatory stimulation. More recently, ventilatory acclimatization has been attributed to accelerated removal of bicarbonate from the cerebrospinal fluid (CSF), producing a metabolic acidosis in the region of the medullary chemoreceptors; but still more recent observations indicate that this process, contrary to earlier observations, does not lower the CSF pH sufficiently to account for the ventilatory stimulation, either. Some other mechanism should be sought.
R H Kellogg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Federation proceedings     Volume:  36     ISSN:  0014-9446     ISO Abbreviation:  Fed. Proc.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0372771     Medline TA:  Fed Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1658-63     Citation Subset:  IM; S    
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MeSH Terms
Anoxia / blood,  cerebrospinal fluid,  physiopathology*
Atmospheric Pressure
Bicarbonates / blood,  cerebrospinal fluid
Carbon Dioxide / blood*
Carotid Body / physiology
Hydrogen-Ion Concentration
Hyperbaric Oxygenation
Kidney / physiology
Medulla Oblongata / physiology
Oxygen / blood*
Time Factors
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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