Document Detail


Oxygen or carbogen breathing before simulated submarine escape.
MedLine Citation:
PMID:  17975127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Raised internal pressure in a distressed submarine increases the risk of bubble formation and decompression illness after submarine escape. The hypothesis that short periods of oxygen breathing before submarine escape would reduce decompression stress was tested, using Doppler-detectable venous gas emboli as a measure. Twelve goats breathed oxygen for 15 min at 0.1 MPa before exposure to a simulated submarine escape profile to and from 2.5 MPa (240 m/seawater), whereas 28 control animals underwent the same dive without oxygen prebreathe. No decompression sickness (DCS) occurred in either of these two groups. Time with high bubble scores (Kisman-Masurel >or=3) was significantly (P < 0.001) shorter in the prebreathe group. In a second series, 30 goats breathed air at 0.2 MPa for 6 h. Fifteen minutes before escape from 2.5 MPa, animals were provided with either air (n = 10), oxygen (n = 12), or carbogen (97.5% O(2) and 2.5% CO(2)) gas (n = 8) as breathing gas. Animals breathed a hyperoxic gas (60% O(2)-40% N(2)) during the escape. Two animals (carbogen group) suffered oxygen convulsions during the escape but recovered on surfacing. Only one case of DCS occurred (carbogen group). The initial bubble score was reduced in the oxygen group (P < 0.001). The period with bubble score of Kisman-Masurel >or=3 was also significantly reduced in the oxygen group (P < 0.001). Oxygen breathing before submarine escape reduces initial bubble scores, although its significance in reducing central nervous system DCS needs to be investigated further.
Authors:
M Gennser; S L Blogg
Related Documents :
14744567 - Neonatal electrocortical brain activity and cerebral tissue oxygenation during non-acid...
9803327 - Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory...
2053727 - Cardiovascular and respiratory effects of thiopental administration in hypovolemic dogs.
10393397 - Bolus versus continuous low dose of enalaprilat in congestive heart failure with acute ...
6337527 - Effect of peep ventilation on renal function, plasma renin, aldosterone, neurophysins a...
14764437 - Acute hemodynamic responses in the head during microgravity induced by free drop in ane...
Publication Detail:
Type:  Journal Article     Date:  2007-11-01
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-02-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
Affiliation:
Swedish Defence Research Agency (FOI), Centre for Environmental Physiology, Karolinska Institute, Stockholm, Sweden. mikaelge@foi.se
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Atmospheric Pressure
Carbon Dioxide / administration & dosage*
Decompression Sickness / etiology,  prevention & control*,  ultrasonography
Embolism, Air / complications,  prevention & control*,  ultrasonography
Female
Goats
Humans
Male
Oxygen / administration & dosage*
Oxygen Inhalation Therapy
Submarine Medicine*
Time Factors
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathe...
Next Document:  Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormon...