| Oxygen Kinetics and Heart Rate Response during Early Recovery from Exercise in Patients with Heart Failure. | |
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MedLine Citation:
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PMID: 22312564 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background. The purpose of this study was to assess the post-exercise O(2) uptake and heart rate response in patients with heart failure (HF) in comparison to healthy individuals. Methods and Results. Exercise testing of all subjects was conducted according to the RITE-protocol. The study subjects were classified according to their peak oxygen uptake (peak VO(2)) in four groups: healthy individuals with a peak VO(2) >22 mL/kg/min (group 1, n: 50), and patients with HF and a peak VO(2) of 18-22 mL/kg/min, (group 2, n: 48), 14-18 mL/kg/min (group 3, n: 57), and <14 mL/kg/min (group 4, n: 31). Both peak VO(2) and HR declined more slowly in the patients with HF than in the normal subjects. Recovery of VO(2) and HR followed monoexponential kinetics in the early post-recovery phase. This enabled the determination of a time constant for both HR and VO(2) (TC VO(2) and TC HR). From group 1 to 4 there was a prolongation of the time constant for VO(2) and HR: TC VO(2) (group 1: 110 ± 34, group 2: 197 ± 43, group 3: 238 ± 80, and group 4: 278 ± 50 sec), and TC HR (group 1: 148 ± 82, group 2: 290 ± 65, group 3: 320 ± 58, and group 4: 376 ± 55 sec). Conclusion. The rate of decline of VO(2) and HR in the early post-exercise phase is inversely related to the peak VO(2). The time constant for oxygen uptake (TC VO(2)) and heart rate (TC HR) might prove a useful parameter for more precise monitoring and grading of HF. |
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Authors:
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Charalampos D Kriatselis; Sotirios Nedios; Sebastian Kelle; Sebastian Helbig; Martin Gottwik; Christian von Bary |
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Publication Detail:
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Type: Journal Article Date: 2012-01-24 |
Journal Detail:
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Title: Cardiology research and practice Volume: 2012 ISSN: 2090-0597 ISO Abbreviation: Cardiol Res Pract Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101516542 Medline TA: Cardiol Res Pract Country: United States |
Other Details:
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Languages: eng Pagination: 512857 Citation Subset: - |
Affiliation:
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The Department of Internal Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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