Document Detail

Oxybutynin: dry days for patients with hyperhidrosis.
MedLine Citation:
PMID:  17057269     Owner:  NLM     Status:  MEDLINE    
We report the case of a 56-year-old postmenopausal woman who was referred to our Endocrinology Outpatient Clinic because of severe hyperhidrosis. She had a four-year history of excessive sweating of her face and upper body. On presentation no sweating could be documented. Physical examination was also unremarkable. It appeared that five days earlier her general practitioner had prescribed oxybutynin for urge incontinence and this accidentally cured her hyperhidrosis. She was diagnosed with idiopathic hyperhidrosis. We advised her to continue the oxybutynin and six months later, she was still symptom-free. Oral anticholinergic drugs are known to be effective for hyperhidrosis, but only anecdotal reports on oxybutynin can be found in the literature. Oxybutynin is not approved for hyperhidrosis, explaining the unfamiliarity with this medicine. This case shows that oxybutynin can be a very effective and simple treatment with only mild side effects. Therefore, oxybutynin merits consideration in patients with idiopathic hyperhidrosis. This report includes a concise review of the causes and treatment options of hyperhidrosis.
G S Mijnhout; H Kloosterman; S Simsek; R J M Strack van Schijndel; J C Netelenbos
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  64     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-12-12     Revised Date:  2008-01-08    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  326-8     Citation Subset:  IM    
Department of Endocrinology, VU University Medical Centre, Amsterdam, the Netherlands.
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MeSH Terms
Hyperhidrosis / drug therapy*
Mandelic Acids / therapeutic use*
Middle Aged
Muscarinic Antagonists / therapeutic use*
Sweat Glands / drug effects
Reg. No./Substance:
0/Mandelic Acids; 0/Muscarinic Antagonists; 5633-20-5/oxybutynin
Comment In:
Neth J Med. 2007 Oct;65(9):356   [PMID:  17954957 ]

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