Document Detail

Oxidized low-density lipoproteins in cord blood from neonates with intra-uterine growth restriction.
MedLine Citation:
PMID:  21324580     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We verified whether oxidative stress indices (oxidized low-density lipoproteins and malondialdehyde) and inflammatory biomarkers (circulating C-reactive protein, interleukin-6, tumour necrosis factor-α, serum amyloid A and soluble intercellular vascular cell adhesion molecule) are increased in the umbilical vein of placental insufficiency induced intra-uterine growth restricted neonates.
STUDY DESIGN: The prospective cohort study, involving 3 tertiary care centers, consists of 200 consecutively recruited pregnant women carrying twins. We chose the twin pregnancy model because both fetuses share the same maternal environment, thereby avoiding potential confounding factors when comparing oxidative stress and inflammation biomarkers. We analysed only twin pairs with one with intra-uterine growth restriction (N=38) defined as fetal growth<10th percentile with abnormal Doppler of the umbilical artery. Blood samples were taken at birth from the umbilical vein. Intra-pair comparisons on the biomarkers were performed using the Student paired t-test.
RESULTS: We observed increased cord blood levels of oxidized low-density lipoproteins, (2.394 ± .412 vs 1.296 ± .204, p=.003) but not of malondialdehyde in growth restricted neonates when compared to their normal counterparts. Although indices of inflammation tended to be increased in cord blood from growth restricted newborns, the difference did not reach statistical significance.
CONCLUSION: In the twin model, intra-uterine growth restriction is associated with low-density lipoprotein oxidation without apparent dysregulation of inflammation biomarkers.
CONDENSATION: Increased oxidized low-density lipoproteins are observed in growth restricted twins compared to their co-twins with normal growth at birth.
Line Leduc; Edgard Delvin; Annie Ouellet; Carole Garofalo; Emilie Grenier; Lucie Morin; Johanne Dubé; Maurice Bouity-Voubou; Jean-Marie Moutquin; Jean-Claude Fouron; Stephanie Klam; Emile Levy
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2011-02-15
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  156     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-24     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics and Gynaecology, Université de Montréal and Research Centre, CHU Sainte-Justine, Quebec, Canada.
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MeSH Terms
Acute-Phase Proteins / analysis
Biological Markers / blood
Cohort Studies
Cytokines / blood
Diseases in Twins / blood,  etiology,  immunology,  physiopathology
Fetal Blood
Fetal Growth Retardation / blood*,  etiology,  immunology
Infant, Newborn
Lipoproteins, LDL / blood*
Malondialdehyde / blood
Oxidative Stress
Placental Insufficiency / physiopathology,  ultrasonography
Pregnancy Proteins / blood
Prospective Studies
Umbilical Arteries / ultrasonography
Vascular Cell Adhesion Molecule-1 / blood
Grant Support
158179//Canadian Institutes of Health Research
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Cytokines; 0/Lipoproteins, LDL; 0/Pregnancy Proteins; 0/Vascular Cell Adhesion Molecule-1; 0/oxidized low density lipoprotein; 542-78-9/Malondialdehyde

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