Document Detail


Oxidized low-density lipoprotein and adiponectin levels in pregnancy.
MedLine Citation:
PMID:  21504339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The aim of the present study was to investigate whether normal pregnancy represents a complex state of oxidative stress, inflammation and insulin resistance.
SUBJECTS AND METHODS: One hundred and six pregnant women, between 24th and 28th week of pregnancy (age 27.9 ± 0.4 years) (study group) and one hundred and six age-matched, healthy, non-pregnant women (control group) participated in the study. Serum levels of glucose, insulin, adiponectin, oxidized LDL (oxLDL) and lipid parameters, i.e. total cholesterol (TC), triglycerides (TG), HDL and LDL, were determined. Body mass index (BMI) and QUantitative Insulin sensitivity ChecK Index (QUICKI) were also calculated.
RESULTS: Pregnant women presented higher BMI values, insulin and oxLDL serum levels and lower glucose serum levels than controls. Serum levels of lipids (TC, TG, LDL and HDL) were higher in pregnant women. There was a significant positive correlation of oxLDL to adiponectin (p < 0.01) in the study group, but not in the controls, and no other significant correlation with any of the other parameters, in either of groups.
CONCLUSIONS: Pregnancy is a state of insulin resistance, oxidative stress and pro-atherogenic hyperlipidemia. Adiponectin may, though, have cardioprotective role in pregnant women.
Authors:
Kali Makedou; Anargyros Kourtis; Athina Gkiomisi; Konstantinos A Toulis; Maria Mouzaki; Athanasios D Anastasilakis; Spyridon Gerou; Elpida Gavana; Theodoros Agorastos
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Publication Detail:
Type:  Journal Article     Date:  2011-04-19
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  27     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-09     Completed Date:  2012-03-22     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1070-3     Citation Subset:  IM    
Affiliation:
4th Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. kali@med.auth.gr
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adult
Atherosclerosis / blood,  etiology
Case-Control Studies
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Female
Humans
Insulin Resistance / physiology
Lipoproteins, LDL / blood*
Oxidative Stress / physiology
Pregnancy / blood*
Pregnancy Complications, Cardiovascular / blood,  etiology
Risk Factors
Triglycerides / blood
Young Adult
Chemical
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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