| Oxidized and free whole blood thiols in preeclampsia. | |
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MedLine Citation:
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PMID: 11165594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure levels of oxidized and free thiols in whole blood of normotensive pregnant and preeclamptic women and evaluate the role of oxidative stress. METHODS: We measured whole blood oxidized and free levels of cysteine, homocysteine, cysteinylglycine, and glutathione by high performance liquid chromatography in women with normotensive pregnancies (n = 50), preeclampsia (n = 29), and preeclampsia complicated by the hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (n = 16). RESULTS: Oxidized and free levels (median [range], micromol/L) of cysteine and homocysteine were higher in women with preeclampsia than normotensive pregnancies (45 [27-81] versus 29 [9-91], P <.001, and 98 [57-193] versus 69 [33-215], P <.001; 0.8 [0.2-4.4] versus 0.4 [0.01-1.6], P <.001, and 2.1 [0.7-9.4] versus 1.2 [0.2-21.2], P <.01; respectively). The ratios of free to oxidized cysteine, homocysteine, and cysteinylglycine were lower in preeclampsia than normotensive pregnancy (2.2 [1.3-3.0] versus 2.4 [1.7-4.3], P <.001; 2.3 [0.5-5.4] versus 2.9 [1.1-24], P <.001; 4.1 [2.3-11.6] versus 5.4 [2.6-24.3], P <.02, respectively), indicating a shift in favor of the oxidized form of those thiols. In HELLP syndrome, levels of oxidized and free cysteine and levels of oxidized homocysteine were higher than normal (44 [33-63] versus 29 [9-91], P <.001, and 102 [82-133] versus 69 [33-215], P <.001; 1.0 [0.3-2.9] versus 0.4 [0.01-1.6], P <.001, respectively). No significant differences were found in oxidized glutathione levels in women with preeclampsia (22 [5-49] versus 17 [2- 60], P =.06) or free levels in preeclamptic women with HELLP syndrome (757 [624-993] versus 842 [539-1516], P =.09) as compared with normotensive pregnant women. The ratios of free to oxidized cysteinylglycine and glutathione were higher in women with HELLP syndrome than in those with preeclampsia (5.4 [3.3-12.7] versus 4.1 [2.3-11.6], P =.02, and 56 [28-124] versus 45 [16-166], P =.02, respectively). CONCLUSION: Significantly lower ratios of free to oxidized cysteine, homocysteine, and cysteinylglycine in preeclampsia might indicate oxidative stress. |
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Authors:
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M T Raijmakers; P L Zusterzeel; E M Roes; E A Steegers; T P Mulder; W H Peters |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 97 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-29 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 272-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology, University Hospital St. Radboud, Nijmegen, Netherlands. w.peters@gastro.azn.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cysteine / blood Dipeptides / blood Female Glutathione / blood HELLP Syndrome / diagnosis, physiopathology Homocysteine / blood Humans Infant, Newborn Lipid Peroxidation / physiology Oxidation-Reduction Oxidative Stress / physiology* Pre-Eclampsia / diagnosis, physiopathology* Pregnancy Reference Values Sulfhydryl Compounds / blood* |
| Chemical | |
Reg. No./Substance:
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0/Dipeptides; 0/Sulfhydryl Compounds; 19246-18-5/cysteinylglycine; 454-28-4/Homocysteine; 52-90-4/Cysteine; 70-18-8/Glutathione |
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