Document Detail


Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy.
MedLine Citation:
PMID:  11254911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the relation between serum lipids including oxidized LDL and the severity of coronary atherosclerosis. Serum lipids and oxidized LDL was measured in 62 men (33-66 years), who underwent diagnostic coronary angiography and sonography to measure the carotid intima-media thickness. LDL oxidation was found in chemical analyses to be due to conjugated fatty acids in cholesteryl esters and triglycerides. Regression analysis indicated that the carotid intima-media thickness and the ratio of LDL diene conjugation to LDL cholesterol (the ox-LDL:LDL ratio) were the only factors associated independently with the severity of coronary atherosclerosis. The patients with multi-vessel disease who did not use lipid lowering therapy had a 50% thicker carotid intima media (P = 0.030) and a 41% higher ox-LDL:LDL ratio (P = 0.020) than patients with normal vessels. Further, patients with multi-vessel disease on statin therapy had a 24% lower ox-LDL:LDL ratio than the subjects with multi-vessel disease who did not use lipid lowering drugs (P = 0.027), although the concentration of LDL cholesterol did not differ between the groups. This study supports the hypothesis that lipid oxidation plays a role in the development of atherosclerosis.
Authors:
T Vasankari; M Ahotupa; J Toikka; J Mikkola; K Irjala; P Pasanen; K Neuvonen; O Raitakari; J Viikari
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  155     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-20     Completed Date:  2001-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  403-12     Citation Subset:  IM    
Affiliation:
Paavo Nurmi Center, Sports Medical Research Unit, Turku, Finland. tommi.vasankari@vierumaki.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticholesteremic Agents / pharmacology,  therapeutic use*
Cardiovascular Agents / pharmacology,  therapeutic use
Carotid Arteries / pathology*
Cholesterol Esters / blood
Comorbidity
Coronary Angiography
Coronary Artery Disease / blood,  drug therapy,  epidemiology,  pathology*
Coronary Vessels / ultrasonography
Fatty Acids / blood
Food Habits
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology,  therapeutic use*
Lipids / blood
Lipoproteins, LDL / blood*
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Triglycerides / blood
Tunica Intima / pathology*
Tunica Media / pathology*
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cardiovascular Agents; 0/Cholesterol Esters; 0/Fatty Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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