| Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy. | |
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MedLine Citation:
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PMID: 11254911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the relation between serum lipids including oxidized LDL and the severity of coronary atherosclerosis. Serum lipids and oxidized LDL was measured in 62 men (33-66 years), who underwent diagnostic coronary angiography and sonography to measure the carotid intima-media thickness. LDL oxidation was found in chemical analyses to be due to conjugated fatty acids in cholesteryl esters and triglycerides. Regression analysis indicated that the carotid intima-media thickness and the ratio of LDL diene conjugation to LDL cholesterol (the ox-LDL:LDL ratio) were the only factors associated independently with the severity of coronary atherosclerosis. The patients with multi-vessel disease who did not use lipid lowering therapy had a 50% thicker carotid intima media (P = 0.030) and a 41% higher ox-LDL:LDL ratio (P = 0.020) than patients with normal vessels. Further, patients with multi-vessel disease on statin therapy had a 24% lower ox-LDL:LDL ratio than the subjects with multi-vessel disease who did not use lipid lowering drugs (P = 0.027), although the concentration of LDL cholesterol did not differ between the groups. This study supports the hypothesis that lipid oxidation plays a role in the development of atherosclerosis. |
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Authors:
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T Vasankari; M Ahotupa; J Toikka; J Mikkola; K Irjala; P Pasanen; K Neuvonen; O Raitakari; J Viikari |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Atherosclerosis Volume: 155 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-20 Completed Date: 2001-06-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 403-12 Citation Subset: IM |
Affiliation:
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Paavo Nurmi Center, Sports Medical Research Unit, Turku, Finland. tommi.vasankari@vierumaki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticholesteremic Agents / pharmacology, therapeutic use* Cardiovascular Agents / pharmacology, therapeutic use Carotid Arteries / pathology* Cholesterol Esters / blood Comorbidity Coronary Angiography Coronary Artery Disease / blood, drug therapy, epidemiology, pathology* Coronary Vessels / ultrasonography Fatty Acids / blood Food Habits Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology, therapeutic use* Lipids / blood Lipoproteins, LDL / blood* Male Middle Aged Oxidation-Reduction Oxidative Stress Triglycerides / blood Tunica Intima / pathology* Tunica Media / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cardiovascular Agents; 0/Cholesterol Esters; 0/Fatty Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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