Document Detail

Oxidized LDL and paraoxanase status in ischemic stroke patients.
MedLine Citation:
PMID:  19585758     Owner:  NLM     Status:  MEDLINE    
Stroke is the leading cause of mortality and long term disability among adults in industrialized countries. Oxidative stress is an independent risk actor by inducing production of oxygen free radicals in ischemic stroke. Because a relationship may be associated between ox-ldl and paraoxanase, the aim of this study was to investigate the association between ox-ldl and paraoxanase in ischemic stroke patients by determining whether ox-ldl is a useful marker for monitoring oxidative stress in ischemic stroke patients. Our study included 100 patients of ischemic stroke and 100 controls. Compared with controls ox-ldl was significantly raised in stroke patients and Paraoxanase activity was low. Our findings suggest that there is a significant association between raised plasma ox-ldl and decrease activity of Paraoxanase with age indicating that plasma ox-ldl may reflect oxidative stress in ischemic stroke patients.
Purnima Dey Sarkar; Sushree S Rautaray
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  52     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Department of Biochemistry, M. G. M. Medical College, Indore.
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MeSH Terms
Aryldialkylphosphatase / blood*
Brain Ischemia / metabolism*
Lipoproteins, LDL / blood*
Middle Aged
Oxidative Stress
Stroke / metabolism*
Reg. No./Substance:
0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; EC

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