| Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin. | |
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MedLine Citation:
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PMID: 22674878 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation. |
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Authors:
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Dmitriy Berillo; Linda Elowsson; Harald Kirsebom |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-4 |
Journal Detail:
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Title: Macromolecular bioscience Volume: - ISSN: 1616-5195 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Biotechnology, Lund University, P.O. Box 124, 22100, Lund, Sweden. Dmitry.Berillo@biotek.lu.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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