| Oxidizability of cardiac cardiolipin in Triton X-100 micelles as determined by using a Clark electrode. | |
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MedLine Citation:
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PMID: 19879863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics of the chain free-radical oxidation of cardiolipin (CL), a unique phospholipid containing four linoleate moieties, have been studied for the first time. The technique based on monitoring oxygen consumption by using a Clark electrode was applied to determine the oxidizability of CL during its initiated oxidation in aqueous Triton X-100 micelles in 50mM phosphate buffer, pH 7.40, at 37 degrees C. The oxidizability was characterized by the k(2)/(sqrt[2k(3)]) ratio, where k(2) and k(3) are the rate constants for the reaction of chain propagation (LO(2)+LH-->LOOH+L) and chain termination (2LO(2)-->products), correspondingly. The oxidizability of CL (in M(-0.5)s(-0.5)) was found to be of 0.62+/-0.07 (calculated on the basis of a single linoleate fragment) that is twice as much than the oxidizability of methyl linoleate (0.32+/-0.04) determined in the same testing systems. It has been shown that the increase in k(2)/(sqrt[2k(3)]) by a factor of two when going from the oxidation of ML to that of CL is almost completely determined by the increase in k(2). |
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Authors:
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Vitaly Roginsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-30 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 163 ISSN: 1873-2941 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 127-30 Citation Subset: IM |
Affiliation:
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N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, 119991 Moscow, Russia. rogin@hotmail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiolipins
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chemistry* Electrodes Kinetics Linoleic Acids / chemistry Micelles* Octoxynol / chemistry* Oxidation-Reduction Oxygen Consumption / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Linoleic Acids; 0/Micelles; 112-63-0/methyl linoleate; 9002-93-1/Octoxynol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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