Document Detail

Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia.
MedLine Citation:
PMID:  15498527     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Lipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. DESIGN AND METHODS: Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy were included in this study. Serum malondialdehyde (MDA) level, an indicator of lipid peroxidation, was measured by high-performance liquid chromatography (HPLC). The oxidizability of apolipoprotein B-containing lipoproteins was evaluated by copper-induced in vitro peroxidation of the isolated fraction of apolipoprotein B-containing lipoproteins coupled with the thiobarbituric acid-reactive substances assay and expressed as the difference between copper-treated MDA and basal MDA (DeltaMDA). The serum paraoxonase and arylesterase activities were determined spectrophotometrically. RESULTS: Serum MDA and DeltaMDA levels of apolipoprotein B-containing lipoproteins were significantly higher in both mild and severe preeclampsia groups than in the normal pregnant group. Serum paraoxonase and arylesterase activities were not significantly different among the study groups. CONCLUSIONS: Enhancement in oxidizability of apolipoprotein B-containing lipoproteins accompanying with dyslipidemia and increased serum MDA levels suggests that those lipoproteins play a role in the pathogenesis of preeclampsia. Further studies are needed to investigate serum paraoxonase activity in women with normal pregnancies and preeclampsia.
Emre Sarandöl; Ozlem Safak; Melahat Dirican; Gürkan Uncu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  37     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-22     Completed Date:  2005-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  990-6     Citation Subset:  IM    
Department of Biochemistry, Medical Faculty, Uludağ University, 16059 Görükle, Bursa, Turkey.
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MeSH Terms
Apolipoproteins B / chemistry*,  metabolism
Aryldialkylphosphatase / blood*
Carboxylic Ester Hydrolases / blood*
Copper / chemistry
Lipid Peroxidation
Lipoproteins / chemistry*,  metabolism
Malondialdehyde / blood
Pre-Eclampsia / enzymology,  metabolism*
Reg. No./Substance:
0/Apolipoproteins B; 0/Lipoproteins; 542-78-9/Malondialdehyde; 7440-50-8/Copper; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC; EC

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