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Oxidised LDL, HDL cholesterol, LDL cholesterol levels in patients of coronary artery disease.
MedLine Citation:
PMID:  23105595     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Coronary artery disease is a major cause of morbidity and has various risk factors. Lipid profile i.e. low HDL-cholesterol, high LDL cholesterol, high total cholesterol, high triglycerides playing important role in its causation. Recently interest has been shown in the oxidized fraction of LDL as one of the risk factors. In the present study 60 age and sex matched normal healthy individuals were taken as controls and 60 patients of CAD were taken. Cholesterol was measured by enzymatic method, HDL cholesterol by phosphotungstate precipitation method. Serum levels of LDL fraction of cholesterol was measured by a new and simpler method of precipitation. Result was expressed as mol/L of diene conjugates. It was observed that LDL cholesterol, VLDL cholesterol, total cholesterol, total cholesterol: HDL cholesterol, LDL cholesterol: HDL cholesterol were significantly raised and HDL cholesterol was significantly low in patients. (p<0.001). Though HDL cholesterol was significantly raised in females as compared to males in both the groups (p<0.001). Serum level of total cholesterol, oxidized LDL:HDL cholesterol were also raised significantly (p<0.05). The level of oxidized LDL showed an increasing trend in patients.
Authors:
Joya Ghosh; T K Mishra; Y N Rao; S K Aggarwal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  21     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Maulana Azad Medical College and associated Lok Nayak Hospital, 110002 New Delhi.
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