Document Detail

Oxidative stress and structure-activity relationship in the zebrafish (Danio rerio) under exposure to paclobutrazol.
MedLine Citation:
PMID:  19089714     Owner:  NLM     Status:  MEDLINE    
The acute toxicity and changes in the activity of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) in the zebrafish Danio rerio were measured when the fish was exposed to paclobutrazol (PBZ) under laboratory conditions. The median lethal concentration value at 96 h post-exposure (LC(50) (96 h)) was determined to be 20.55 mg/L. In addition, the SOD activities in D. rerio were significantly higher at 96 h post-exposure among the various concentrations of the pollutant tested. The change of CAT activity could be considered as a sensitive biomarker of the oxidative stress induced by PBZ. The structure-activity relationship (SAR) analysis identified the potential active points for the pollutant and that the cavum may be the site of interaction with the receptor.
Feng Ding; Wen H Song; Jing Guo; Min L Gao; Wei X Hu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes     Volume:  44     ISSN:  1532-4109     ISO Abbreviation:  J Environ Sci Health B     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-02-26     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  7607167     Medline TA:  J Environ Sci Health B     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
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MeSH Terms
Acute Toxicity Tests
Antioxidants / metabolism*
Catalase / metabolism
Oxidative Stress / drug effects*
Structure-Activity Relationship
Superoxide Dismutase / metabolism
Time Factors
Triazoles / chemistry*,  metabolism,  toxicity*
Zebrafish / metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Triazoles; 76738-62-0/paclobutrazol; EC; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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