Document Detail

Oxidative stress status in patients with diabetes mellitus: relationship to diet.
MedLine Citation:
PMID:  12879095     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between dietary intakes and in vivo oxidative stress (OS) status in diabetic patients. DESIGN: Case-control study. SETTING: Outpatient-Clinic and Laboratory Endocrinology, University Antwerp. SUBJECTS AND METHODS: A total of 30 patients (24 type 1 diabetes mellitus (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1 weekend day food consumption questionnaire during the week preceding their yearly diabetes control consultation, when samples were collected for the assay of oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde (MDA) and minerals). Blood samples were also collected from 25 age- and sex-matched healthy controls. RESULTS: Diabetic patients had lower glutathione (5.80+/-1.15 vs 6.75+/-1.03 micromol/g Hb in the controls, P=0.002) and higher MDA (0.687+/-0.212 vs 0.545+/-0.101 micromol/l, P=0.002). Although the group average intakes were within the Belgian RDA, intakes of fat >35% energy, fibre <15 g/1000 kcal, fruit <2 portions and vitamin E <10 mg/day were seen in more than 20 patients. Blood antioxidants did not correlate with intakes of energy, fat, protein or fibres or of their respective antioxidant. Vitamins A and E correlated with serum lipids (r=0.58, P <0.0005 between serum alpha-tocopherol and cholesterol). Blood peroxide levels were only related to intakes of saturated fat and cholesterol (P<0.05). In diabetic subjects but not in controls (P<0.05) MDA was related to glutathione and uric acid. CONCLUSIONS: In diabetic patients, blood levels of antioxidants are not related to their dietary intakes but to serum lipids. Levels of oxidative damage products are only related to intakes of saturated fats and cholesterol and to levels of endogenous antioxidants.
N Dierckx; G Horvath; C van Gils; J Vertommen; J van de Vliet; I De Leeuw; B Manuel-y-Keenoy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  57     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-24     Completed Date:  2003-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  999-1008     Citation Subset:  IM    
Laboratory of Endocrinology, University of Antwerp, Belgium.
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MeSH Terms
Aged, 80 and over
Antioxidants / administration & dosage,  metabolism*
Case-Control Studies
Diabetes Mellitus, Type 1 / blood*
Diabetes Mellitus, Type 2 / blood*
Diet Records
Glutathione / blood
Lipid Peroxidation
Malondialdehyde / blood
Middle Aged
Oxidative Stress / physiology*
Reg. No./Substance:
0/Antioxidants; 542-78-9/Malondialdehyde; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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