| Oxidative stress and role of antioxidant supplementation in critical illness. | |
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MedLine Citation:
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PMID: 17447658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sepsis or systemic inflammatory response (SIRS) to infection or to non-infectious stimuli such as trauma, surgery, pancreatitis or ischemia, is an increasingly common cause of morbidity and mortality in patients on intensive therapy unit (ITU). In critically ill patients, this accounts for 10% to 50% of all deaths. Oxidative stress has an important role in the development and manifestations of SIRS. Oxidative stress is an imbalance between the free radical production and the antioxidant defense. In critical illness, overwhelming inflammatory mediator response to infective or non-infective stimuli results in excessive production of free radicals (FR). The action of FR is normally limited by the antioxidant defense system of the body, but in critically ill patients the antioxidant capacity is likely to be compromised. Hence, provision of antioxidants to critically ill patients may help in removing the FR and therefore improving the clinical outcome. However, no study has yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in critically ill patients. The clinical evidence provided so far shows that there are several factors which might determine the efficacy of antioxidant supplementation in critically ill patients. There is a need for large multicentre prospective randomized control trials to assess the effects of different types and doses of antioxidant supplementation in selected groups of patients with different types of critical illness. |
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Authors:
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Vinita Mishra |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical laboratory Volume: 53 ISSN: 1433-6510 ISO Abbreviation: Clin. Lab. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-23 Completed Date: 2007-05-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9705611 Medline TA: Clin Lab Country: Germany |
Other Details:
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Languages: eng Pagination: 199-209 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UK. Vinita.mishra@rlbuht.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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therapeutic use* Critical Illness / mortality*, therapy* Dietary Supplements Free Radicals / metabolism Humans Models, Biological Oxidative Stress / drug effects* Randomized Controlled Trials as Topic Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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