Document Detail

Oxidative stress responses in older men during endurance training and detraining.
MedLine Citation:
PMID:  15570141     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Aging is associated with increased oxidative stress, whereas systematic exercise training has been shown to improve quality of life and functional performance of the aged. This study aimed to evaluate responses of selected markers of oxidative stress and antioxidant status in inactive older men during endurance training and detraining. METHODS: Nineteen older men (65-78 yr) were randomly assigned into either a control (C, N = 8) or an endurance-training (ET, N = 11, three training sessions per week, 16 wk, walking/jogging at 50-80% of HR(max)) group. Before, immediately posttraining, and after 4 months of detraining, subjects performed a progressive diagnostic treadmill test to exhaustion (GXT). Plasma samples, collected before and immediately post-GXT, were analyzed for malondialdehyde (MDA) and 3-nitrotyrosine (3-NT) levels, total antioxidant capacity (TAC), and glutathione peroxidase activity (GPX). RESULTS: ET caused a 40% increase in running time and a 20% increase in maximal oxygen consumption (VO(2max)) (P < 0.05). ET lowered MDA (9% at rest, P < 0.01; and 16% postexercise, P < 0.05) and 3-NT levels (20% postexercise, P < 0.05), whereas it increased TAC (6% at rest, P < 0.01; and 14% postexercise, P < 0.05) and GPX (12% postexercise, P < 0.05). However, detraining abolished these adaptations. CONCLUSIONS: ET may attenuate basal and exercise-induced lipid peroxidation and increase protection against oxidative stress by increasing TAC and GPX activity. However, training cessation may reverse these training-induced adaptations.
Ioannis G Fatouros; Athanasios Z Jamurtas; Vasiliki Villiotou; Sofia Pouliopoulou; Panagiotis Fotinakis; Kiriakos Taxildaris; George Deliconstantinos
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  36     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-30     Completed Date:  2005-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2065-72     Citation Subset:  IM; S    
Democritus University of Thrace, Department of Physical Education and Sport Science, 7th km of National Rd. Komotini-Xanthi, Komotini, 69100, Greece.
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MeSH Terms
Aging / physiology*
Antioxidants / analysis
Exercise / physiology*
Exercise Test
Exercise Therapy*
Lipid Peroxidation
Oxidative Stress*
Physical Endurance
Reg. No./Substance:

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