| Oxidative stress is related to exercise intolerance in patients with heart failure. | |
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MedLine Citation:
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PMID: 9453530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the role of oxidative stress in exercise intolerance in patients with heart failure, a symptom-limited exercise test was performed with a bicycle ergometer in 12 patients with heart failure and in 7 members of a healthy control group. Level of plasma malondialdehyde, a marker of lipid peroxidation, at rest was significantly higher in patients than in the control group. The level further increased at peak exercise in patients but not in the control group. A significant inverse correlation was observed in patients between exercise-induced changes in malondialdehyde level and erythrocyte superoxide dismutase activity (r = -0.73, p < 0.01), and those exercise-induced changes in malondialdehyde level and superoxide dismutase activity had a close correlation with peak VO2 (r = -0.63, p < 0.05 and r = 0.67, p < 0.05, respectively), whereas no such correlation was observed in the control group. These findings suggest that the oxidative stress could be related to exercise intolerance in patients with heart failure. |
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Authors:
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Y Nishiyama; H Ikeda; N Haramaki; N Yoshida; T Imaizumi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 135 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-10 Completed Date: 1998-02-10 Revised Date: 2008-01-22 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: AIM; IM |
Affiliation:
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Third Department of Internal Medicine, Kurume University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Exercise Test Exercise Tolerance* Female Free Radicals / metabolism Heart Failure / metabolism*, physiopathology* Hemodynamics Humans Male Malondialdehyde / blood* Middle Aged Oxidative Stress* Oxygen Consumption Superoxide Dismutase / blood* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 542-78-9/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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