Document Detail

Oxidative stress is related to exercise intolerance in patients with heart failure.
MedLine Citation:
PMID:  9453530     Owner:  NLM     Status:  MEDLINE    
To assess the role of oxidative stress in exercise intolerance in patients with heart failure, a symptom-limited exercise test was performed with a bicycle ergometer in 12 patients with heart failure and in 7 members of a healthy control group. Level of plasma malondialdehyde, a marker of lipid peroxidation, at rest was significantly higher in patients than in the control group. The level further increased at peak exercise in patients but not in the control group. A significant inverse correlation was observed in patients between exercise-induced changes in malondialdehyde level and erythrocyte superoxide dismutase activity (r = -0.73, p < 0.01), and those exercise-induced changes in malondialdehyde level and superoxide dismutase activity had a close correlation with peak VO2 (r = -0.63, p < 0.05 and r = 0.67, p < 0.05, respectively), whereas no such correlation was observed in the control group. These findings suggest that the oxidative stress could be related to exercise intolerance in patients with heart failure.
Y Nishiyama; H Ikeda; N Haramaki; N Yoshida; T Imaizumi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  135     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-10     Completed Date:  1998-02-10     Revised Date:  2008-01-22    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  AIM; IM    
Third Department of Internal Medicine, Kurume University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Exercise Test
Exercise Tolerance*
Free Radicals / metabolism
Heart Failure / metabolism*,  physiopathology*
Malondialdehyde / blood*
Middle Aged
Oxidative Stress*
Oxygen Consumption
Superoxide Dismutase / blood*
Reg. No./Substance:
0/Free Radicals; 542-78-9/Malondialdehyde; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Improvement in the mechanical efficiency of walking: an explanation for the "placebo effect" seen du...
Next Document:  Beneficial effects of intermittent home administration of the inotrope/vasodilator milrinone in pati...