Document Detail

Oxidative stress is not enhanced in non-malnourished infants with persistent diarrhea.
MedLine Citation:
PMID:  11695727     Owner:  NLM     Status:  MEDLINE    
Increased concentrations of reactive oxygen species (ROS) and depleted antioxidant defences have been implicated in a cycle of infection, malabsorption and malnutrition, leading to persistent diarrhea. In order to determine whether in non-malnourished children oxidative stress predisposes to the development of persistent diarrhea, infants with acute diarrhea (< 7 days) (n = 39) were compared to infants with persistent diarrhea (> 14 days) (n = 38). Lipid peroxidation was assessed by the TBARs assay and expressed as malondialdehyde equivalent content (nmol MDA/ml plasma), and levels of plasma antioxidants vitamin A and vitamin E were determined. In infants with acute and persistent diarrhea nutritional status, as assessed by weight/height and height-for-age, hemoglobin levels, serum albumin and immunoglobulin levels, did not differ between groups. Serum vitamin A and vitamin E levels did not differ in infants with acute or persistent diarrhea. TBARs, expressed as nmol MDA/ml plasma did not differ between infants with acute or persistent diarrhea and furthermore did not differ from levels in a healthy, similar age, control group. Non-malnourished infants with persistent diarrhea do not exhibit plasma antioxidant depletion or enhanced lipid peroxidation. In these infants, oxidative stress, as reflected in plasma, does not play a role in the pathogenesis of persistent diarrhea.
E Granot; M Binsztok; D Fraser; R J Deckelbaum; Z Weizman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  47     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-06     Completed Date:  2001-12-13     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  284-7     Citation Subset:  IM    
Department of Pediatrics, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Analysis of Variance
Child, Preschool
Chronic Disease
Diarrhea / blood*,  microbiology
Lipid Peroxidation
Nutrition Disorders / blood*
Oxidative Stress*
Reactive Oxygen Species / blood
Vitamin A / blood
Vitamin E / blood
Reg. No./Substance:
0/Reactive Oxygen Species; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E

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