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Oxidative stress and myocardial remodeling in chronic mitral regurgitation.
MedLine Citation:
PMID:  21795957     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mechanisms of left ventricular (LV) dysfunction in isolated mitral regurgitation (MR) are not well understood. Vasodilator therapy in other forms of LV dysfunction reduces LV wall stress and improves LV function; however, studies in isolated MR show no beneficial effect on LV remodeling using vasodilator drugs or renin-angiotensin system blockade. Therefore, the search for new therapies that improve LV remodeling and function in isolated MR is clinically significant. Recent work in the authors' laboratory has demonstrated increased oxidants from a number of sources including the enzyme xanthine oxidase (XO) in the LV of patients with isolated MR. In addition to being a major source of reactive oxygen species, XO is linked to bioenergetic dysfunction because its substrates derive from adenosine triphosphate catabolism. Correspondingly, there was also evidence of aggregates of small mitochondria in cardiomyocytes, which is generally considered a response to bioenergetic deficit in cells. Future studies are required to determine whether XO and persistent oxidative stress are causative in maladaptive LV remodeling and offer potential therapeutic targets in ameliorating LV damage in patients with isolated MR.
Authors:
James D Gladden; Mustafa I Ahmed; Silvio H Litovsky; Chun G Schiros; Steven G Lloyd; Himanshu Gupta; Thomas S Denney; Victor Darley-Usmar; David C McGiffin; Louis J Dell'italia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  342     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  AIM; IM    
Affiliation:
From the Center for Heart Failure Research, Departments of Medicine, Pathology, and Biostatistics, and Divisions of Cardiovascular Disease and Cardiovascular Surgery (jdg, mia, shl, sgl, hg, vd-u, dcm, ljd), University of Alabama at Birmingham; Department of Medicine and Division of Cardiology (SGL, HG, LJD), Birmingham Veteran Affairs Medical Center; and Department of Electrical and Computer Engineering (CGS, TSD), Auburn University Samuel Ginn College of Engineering, Birmingham, Alabama.
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