| Oxidative stress and 'monocyte reprogramming' in septic patients with acute kidney injury requiring CRRT. | |
| | |
MedLine Citation:
|
PMID: 18277069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative stress (OS) and monocyte HLA-DR expression are known to be predictive of mortality in sepsis; nevertheless, limited information exists regarding sepsis with acute kidney injury (AKI). The aim of the study was to correlate these markers with outcome in septic patients with AKI requiring continuous renal replacement therapy (CRRT). Advanced oxidation protein products (AOPP) were measured in 32 patients on days 1, 3, 7, 14, 21, and 28. In 14 we assessed the percentage of monocytes expressing HLA-DR (%DR+) and the HLA-DR mean fluorescence intensity (MFI). 20 healthy volunteers, 17 septic patients without AKI and 20 septic AKI patients not treated by CRRT were used for comparison. The mortality rate was 59%. Septic CRRT patients had higher AOPP and lower %DR+ (p < 0.001, both) than healthy controls. They also had higher AOPP than septic patients who did not develop AKI (p < 0.001). No difference was found in AOPP, %DR+ and MFI between survivors and non-survivors (day 1 and subsequent measurements). No correlation was seen between severity scores and OS/HLA-DR. OS and HLA-DR expression are altered in septic patients with AKI undergoing CRRT. However, this study was not able to confirm the usefulness of these markers in predicting survival in this subset of patients. |
| | |
Authors:
|
Sandra Silva; Massimo de Cal; Dinna Cruz; Paolo Lentini; Valentina Corradi; Giampiero Gallo; Gabriella Salvatori; Anton Verbine; Lusine Pogoshyan; Federico Nalesso; Alessandra Brendolan; Pasquale Piccinni; Claudio Ronco |
Related Documents
:
|
10464899 - Compliance with ltot and consumption of mobile oxygen. 17925639 - Electrical burns in chinese fishermen using graphite rods under high-voltage cables. 1994949 - Tension pneumothorax associated with hyperbaric oxygen therapy. 22397469 - Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chro... 9295829 - Dramatic effect on oxygenation in patients with severe acute lung insufficiency treated... 20890859 - Can hyperbaric oxygenation therapy (hot) modify the blood testosterone concentration? 19481939 - Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2 myotonic dy... 20938099 - Characteristics of revascularization treatment for arteriosclerosis obliterans in patie... 19325909 - Response monitoring in de novo patients with parkinson's disease. |
Publication Detail:
|
Type: Journal Article Date: 2008-02-15 |
Journal Detail:
|
Title: Blood purification Volume: 26 ISSN: 1421-9735 ISO Abbreviation: Blood Purif. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-03-19 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 188-92 Citation Subset: IM |
Copyright Information:
|
Copyright 2008 S. Karger AG, Basel. |
Affiliation:
|
Department of Nephrology, Dialysis and Transplant, St. Bortolo Hospital, Vicenza, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Case-Control Studies Female HLA-DR Antigens Humans Kidney Diseases / etiology*, mortality Male Middle Aged Monocytes / immunology* Oxidative Stress* / immunology Prognosis Prospective Studies Renal Replacement Therapy* Sepsis / complications*, metabolism, mortality Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/HLA-DR Antigens |
| Comments/Corrections | |
Comment In:
|
Blood Purif. 2008;26(2):186-7
[PMID:
18277068
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular h...
Next Document: Influence of beverage composition on the results of erosive potential measurement by different measu...