| Oxidative stress and metabolism at rest and during exercise in persons with Down syndrome. | |
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MedLine Citation:
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PMID: 18277183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Down syndrome (DS) is a risk factor for metabolic syndrome and cardiovascular disease. The greater oxidative stress described in DS can increase this risk owing to its potential deleterious effects on insulin sensitivity. We hypothesized that metabolic syndrome or its markers, at rest and during exercise, are more pronounced in young adults with DS. DESIGN: The study design is that of a controlled study. METHODS: Thirteen physically active young adults with DS, after overnight polysomnography, plasma-lipid profile, and insulin-resistance [Homeostasis Model Assessment Insulin Resistance (HOMA-IR)] assessments, underwent a submaximal progressive treadmill exercise (10 min at 30 and 50%, and 20 min at 75% of V O2max), allowing for maximal fat-oxidation rate and blood-oxidative stress determinations. They were compared with 15 healthy control participants (C). RESULTS: V O2max of DS participants was lower than that of C (60.8+/-2.4 versus 44.4+/-3.3 ml/kg/min; P<0.001) but was close to the predicted value (95+/-6%). In DS participants, as expected, oxidative stress was greater than in C (+15%; P<0.001) at rest and all through the exercise protocol. Although a greater fat mass (DS: 19.9+/-1.3%; C: 13.5+/-0.9%; P<0.001), and a lower insulin sensitivity (HOMA-IR in DS: 1.09+/-0.16; in C: 0.64+/-0.13; P<0.05) was observed for DS participants, a metabolic syndrome could not be shown. Maximal fat-oxidation rate was lower in DS participants (394.2+/-69.9 versus 486.1+/-134.8 mg/min in C; P<0.01), but it was in the normal range. CONCLUSION: Despite greater oxidative stress and lower insulin sensitivity, the DS group involved in our study did not display clear metabolic abnormalities. The young age and lifestyle of this group might, partially, have accounted for this apparently healthy metabolic status. |
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Authors:
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Patrice Flore; Véronique-A Bricout; Debbie van Biesen; Michel Guinot; François Laporte; Jean-Louis Pépin; Yves Eberhard; Anne Favre-Juvin; Bernard Wuyam; Peter van de Vliet; Patrice Faure |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 15 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 35-42 Citation Subset: IM |
Affiliation:
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Grenoble 1 University (Joseph Fourier) (UFRAPS and UFR Santé), IFR 1, Research on Exercise and Health Laboratory, South Hospital, Grenoble University Hospital, Grenoble cedex, France. PFlore@chu-grenoble.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Pressure Determination Case-Control Studies Down Syndrome / metabolism*, physiopathology* Exercise / physiology* Exercise Test Humans Insulin Resistance Male Oxidative Stress* Polysomnography Rest |
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