| Oxidative stress markers in patients with primary open-angle glaucoma. | |
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MedLine Citation:
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PMID: 20373896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the levels of antioxidant enzymes catalase (CAT), glutathione peroxidase (GPO), superoxide dismutase (SOD), and malondialdehyde (MDA) in human eyes with primary open-angle glaucoma (POAG) and to correlate their concentrations with severity of glaucoma. DESIGN: A prospective cases control study. PATIENTS AND METHODS: Thirty patients with primary open-angle glaucoma and twenty-five patients with senile cataracts of matched age and gender were included in the study prospectively. Aqueous humor samples were obtained by paracentesis at the time of elective surgery for glaucomatous and cataractous patients. Aqueous humor were analyzed for CAT, GPO, SOD, and MDA status. RESULTS: GPO, SOD, and MDA enzyme levels revealed a high significant increase in aqueous humor of POAG patients with respect to the comparative group of cataract patients (P < 0.001). No significant difference in the activity of CAT enzyme in aqueous humor of POAG and cataract patient (P = 0.201). Significant correlation was found between the MDA enzyme level and severe visual field loss (P < 0.001) in POAG patients. CONCLUSION: Increased levels of aqueous humor GPO, SOD, and MDA may be associated with POAG. In addition, they may be useful antioxidant enzyme levels in aqueous humor of POAG patients as a result of glaucoma disease and not a cause. |
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Authors:
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Asaad A Ghanem; Lamiaa F Arafa; Ayman El-Baz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current eye research Volume: 35 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Faculty of Medicine, Mansoura University, Egypt. asaadghanem@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants Aqueous Humor / enzymology* Biological Markers / metabolism* Case-Control Studies Catalase / metabolism Cataract / metabolism Female Glaucoma, Open-Angle / enzymology* Glutathione Peroxidase / metabolism Humans Male Malondialdehyde / metabolism Middle Aged Oxidative Stress* Prospective Studies Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 542-78-9/Malondialdehyde; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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