Document Detail

Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants.
MedLine Citation:
PMID:  17586185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether our current practice of giving iron 18 mg daily to 6-week-old infants with very low birth weight (VLBW) was associated with increased oxidative stress markers or decreased antioxidant status. STUDY DESIGN: The study was a prospective observational study of 21 healthy VLBW infants (born at gestational age <32 weeks, birth weight <1500 g). Blood and urine were sampled twice before starting iron supplementation at 6 weeks postnatal age and after 1 week of iron supplementation at age 7 weeks. Urine 8-isoprostane was analyzed by gas chromatography-mass spectrometry and plasma total hydroperoxides were measured. Antioxidant status was assessed by ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), ferric-reducing ability of plasma, and plasma glutathione. RESULTS: After 1 week of iron supplementation, no significant changes in urine 8-isoprostane or plasma total hydroperoxides were seen, and plasma antioxidants were largely unchanged. CONCLUSIONS: Markers of oxidative stress in urine and plasma antioxidant status in healthy VLBW infants fed human milk remained unchanged after high-dose oral iron supplementation.
Kristin Braekke; Anne Grete Bechensteen; Bente Lise Halvorsen; Rune Blomhoff; Kirsti Haaland; Anne Cathrine Staff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  151     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-23     Revised Date:  2008-07-25    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  AIM; IM    
Pediatric Intensive Care Unit, Ulleval University Hospital, Oslo, Norway.
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MeSH Terms
Administration, Oral
Antioxidants / metabolism*
Biological Markers / blood
Cohort Studies
Confidence Intervals
Dietary Supplements
Dose-Response Relationship, Drug
Drug Administration Schedule
Ferrous Compounds / administration & dosage*
Follow-Up Studies
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care Units, Neonatal
Oxidative Stress / drug effects*,  physiology
Prospective Studies
Risk Factors
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Ferrous Compounds; 141-01-5/ferrous fumarate
Comment In:
J Pediatr. 2008 Feb;152(2):295-6; author reply 296   [PMID:  18206709 ]
J Pediatr. 2007 Jul;151(1):3-4   [PMID:  17586179 ]
J Pediatr. 2008 Jun;152(6):890-1; author reply 891   [PMID:  18492540 ]

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