| Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 16730727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the levels of 3 oxidative stress markers (glutathione peroxidase [GPX], superoxide dismutase [SOD], and malondialdehyde [MDA]) and 2 antioxidants (vitamin C and lycopene) in healthy and pre-eclamptic pregnant women. METHODS: Circulating levels of GPX, SOD, MDA, vitamin C and lycopene were measured in 50 healthy pregnant women and 50 women with pre-eclampsia (PE) (41 with mild PE and 9 with severe PE) attending the antenatal clinic or admitted to the maternity ward of the All-India Institute of Medical Sciences, New Delhi, India. RESULTS: The levels of GPX, SOD and MDA were significantly higher in women with PE than in controls, and the increase was higher in women with severe PE (P<0.001 using analysis of variance and the Kruskal Wallis test). The levels of vitamin C and lycopene were significantly lower in women with PE than in controls, with a greater decrease in women with severe PE. CONCLUSION: Increased levels of oxidative stress markers and decreased levels of antioxidants in pre-eclamptic women suggest that oxidative stress markers play a significant role in the pathophysiology of pre-eclampsia, and that supplemental dietary antioxidants may have a beneficial role in the prevention of pre-eclampsia in women at high-risk for this condition. |
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Authors:
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J B Sharma; A Sharma; A Bahadur; N Vimala; A Satyam; S Mittal |
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Publication Detail:
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Type: Journal Article Date: 2006-05-30 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 94 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-04 Completed Date: 2006-11-28 Revised Date: 2013-04-23 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, All-India Institute of Medical Sciences, New Delhi, India. jbsharma2000@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / analysis* Ascorbic Acid / blood Carotenoids / blood Dietary Supplements Female Humans Malondialdehyde / blood Oxidative Stress / physiology* Pre-Eclampsia / blood*, physiopathology*, prevention & control Pregnancy / physiology* Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 36-88-4/Carotenoids; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase; SB0N2N0WV6/lycopene |
| Comments/Corrections | |
Erratum In:
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Int J Gynaecol Obstet. 2013 Apr;121(1):96 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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