| Oxidative stress: key player in gastrointestinal complications of diabetes. | |
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MedLine Citation:
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PMID: 21226884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrointestinal dysmotility presenting as nausea, vomiting, bloating, diarrhea, constipation or abdominal pain is seen in diabetic patients. Oxidative stress has recently been recognized as a significant player in the pathogenesis of gastrointestinal complications of diabetes. In this issue of Neurogastroenterology and Motility, a team of investigators from Emory University led by Dr. Srinivasan present new evidence on the effect of oxidative stress in the diabetic colon. They show in diabetic patients, increased oxidative stress is associated with loss of the inhibitory neuronal subpopulation of enteric neurons, and that the neuronal loss can be reversed in-vitro by anti-oxidant lipoic acid. This new information adds to the accumulating evidence on the deleterious effect of oxidative stress in the gastrointestinal tract and highlights the opportunity to develop newer therapies focused on augmenting anti-oxidant defenses in the gastrointestinal tract in diabetic patients. |
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Authors:
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P Kashyap; G Farrugia |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 23 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-13 Completed Date: 2011-06-17 Revised Date: 2012-03-09 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 111-4 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology Apoptosis / drug effects Cell Line Colon / innervation, physiopathology Diabetes Complications / complications* Disease Models, Animal Enteric Nervous System / cytology, drug effects, physiopathology* Gastrointestinal Diseases / etiology*, physiopathology* Gastrointestinal Motility / physiology Humans Mice Oxidative Stress / physiology* Reactive Oxygen Species / metabolism Thioctic Acid / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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DK 68055/DK/NIDDK NIH HHS; P01 DK068055-05/DK/NIDDK NIH HHS; P01 DK068055-050001/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Reactive Oxygen Species; 62-46-4/Thioctic Acid |
| Comments/Corrections | |
Comment On:
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Neurogastroenterol Motil. 2011 Feb;23(2):131-8, e26
[PMID:
20939847
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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