| Oxidative stress and inflammation are associated with adiposity in moderate to severe CKD. | |
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MedLine Citation:
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PMID: 18256365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adiposity contributes to inflammation and oxidative stress in the general population, but this association has not been examined in the chronic kidney disease (CKD) population. We investigated the relationship between body mass index, body fat percentage, and markers of inflammation (C-reactive protein) and oxidative stress (F(2)-isoprostanes and protein thiols) in 184 patients with stages III to IV CKD and 43 healthy controls. We found that, on average, patients with CKD had 62% higher F(2)-isoprostanes, 7% lower protein thiols (a measure of endogenous anti-oxidant capacity, inversely related to protein oxidation), and 150% higher C-reactive protein levels than healthy controls (all unadjusted P < 0.001). In separate multivariable linear regression models, body mass index and body fat percentage each positively correlated with levels of F(2)-isoprostanes and C-reactive protein and negatively correlated with levels of protein thiols among patients with CKD after adjusting for age, sex, race, hypertension, diabetes mellitus, smoking history, estimated glomerular filtration rate, total cholesterol, serum albumin, and study site. We conclude that increased adiposity may amplify the oxidative stress and inflammation that accompany moderate to severe CKD. Interventions focused on weight loss may decrease the inflammatory and oxidative burden in CKD, which may ultimately attenuate cardiovascular risk in this population. |
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Authors:
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Luis F Ramos; Ayumi Shintani; T Alp Ikizler; Jonathan Himmelfarb |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-02-06 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 19 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-29 Completed Date: 2008-03-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 593-9 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Renal Transplantation and Clinical and Translational Research, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102. himmej@mmc.org. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Body Mass Index* C-Reactive Protein / metabolism Case-Control Studies Cross-Sectional Studies F2-Isoprostanes / blood Female Glomerular Filtration Rate / physiology* Humans Inflammation / complications, metabolism* Kidney Failure, Chronic / complications, metabolism* Lipid Peroxidation / physiology Male Middle Aged Obesity / complications, metabolism* Oxidation-Reduction Oxidative Stress / physiology* Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK-20593/DK/NIDDK NIH HHS; K24 DK62849/DK/NIDDK NIH HHS; R01 DK45604/DK/NIDDK NIH HHS; R01 HL070938/HL/NHLBI NIH HHS; UL1 RR024975/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/F2-Isoprostanes; 0/Proteins; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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