Document Detail


Oxidative stress increases in carbon monoxide poisoning patients.
MedLine Citation:
PMID:  21041241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Carbon monoxide poisoning (COP) is one of the important causes of morbidity and mortality in toxicological cases. In this study, we aimed to find out more about the pathophysiology of COP by investigating the effects of COP on oxidative stress parameters such as total oxidant status (TOS) and total antioxidant status (TAS).
METHODS: Eighty-eight patients admitted to the emergency department of our hospital with acute COP and 35 healthy adults as control group were included in this study. Blood samples were collected from all COP patients at the time of initial emergency department evaluation to determine the oxidative stress parameters. Then, serum levels of total antioxidant status and total oxidant status levels were measured.
RESULTS: A total of 88 patients poisoned by carbon monoxide (CO; mean age 37.1 ± 18.2 years; 54'% women) were enrolled. TOS and carboxyhemoglobin (COHb) levels in COP patients were increased when compared to control group (p = 0.001). TOS, oxidative stress index (OSI) and COHb levels in COP patients were significantly lower after the treatment. (respectively, p = 0.016; p = 0.023; p = 0.001). On the other hand, no statistical differences were observed in TAS levels of study and control group as well as there were no changes with treatment.
CONCLUSION: Measurements of TOS, TAS and OSI levels may be useful markers to find out the pathophsiology of COP.
Authors:
Havva Sahin Kavakli; Ozcan Erel; Orhan Delice; Gizem Gormez; Semra Isikoglu; Fatih Tanriverdi
Publication Detail:
Type:  Journal Article     Date:  2010-11-01
Journal Detail:
Title:  Human & experimental toxicology     Volume:  30     ISSN:  1477-0903     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-05-12     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / metabolism*
Biological Markers / blood
Carbon Monoxide Poisoning / blood,  metabolism*,  therapy
Carboxyhemoglobin / analysis
Case-Control Studies
Female
Humans
Hyperbaric Oxygenation
Male
Oxidants / blood*
Oxidative Stress*
Oxygen Inhalation Therapy / methods*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Oxidants; 9061-29-4/Carboxyhemoglobin
Comments/Corrections
Comment In:
Hum Exp Toxicol. 2013 Apr;32(4):444-5   [PMID:  22859659 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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