Document Detail

Oxidative stress in university students during examinations.
MedLine Citation:
PMID:  15764015     Owner:  NLM     Status:  MEDLINE    
Mental stress in psychiatric disease and in daily life contributes to oxidative stress in the body. In this study we investigated a connection between possible psychological stress caused by university undergraduate examinations and oxidative stress experienced by our test subjects. Some parameters of oxidative stress (single strand breaks of DNA in lymphocytes, sensitivity to lipid oxidation and antioxidant status) were studied in medical students on the day of the examination (stress condition) and compared with the same parameters obtained from the same students during the term between two examination periods (non-stress condition). The results show that in the stress condition oxidative damage to DNA and sensitivity to lipid oxidation were significantly increased (p<0.05) when compared with the same parameters in "non-stress" conditions. A significant decrease in plasma antioxidant activity (p<0.05) in students that were under stress was observed. These results suggest that during university examinations students are under increased oxidative stress.
Monika Sivonová; Ingrid Zitnanová; Lucia Hlincíková; Igor Skodácek; Jana Trebatická; Zdenka Duracková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  7     ISSN:  1025-3890     ISO Abbreviation:  Stress     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-03-14     Completed Date:  2005-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava 81372, Slovak Republic.
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MeSH Terms
Blood Proteins / metabolism
Comet Assay
DNA Damage / physiology
Educational Measurement*
Ferric Compounds / metabolism
Lipid Peroxidation / physiology
Lipoproteins / metabolism
Lymphocytes / metabolism*
Oxidative Stress / physiology*
Stress, Psychological / metabolism*
Reg. No./Substance:
0/Blood Proteins; 0/Ferric Compounds; 0/Lipoproteins

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