| Oxidative stress in twin neonates is influenced by birth weight and weight discordance. | |
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MedLine Citation:
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PMID: 21349257 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the extent of oxidative stress in neonates born from multiple gestation pregnancies, who are at high risk of prematurity and growth abnormalities. DESIGN AND METHODS: Blood samples were collected from umbilical cord of 72 twins, born at gestational age of 28 - 38 weeks, and 20 consecutive control singletons. Oxidative stress parameters (15-F(2t)-isoprostane, a marker of lipid peroxidation, and total antioxidant capacity, tAOC), were measured in cord plasma. RESULTS: 15-F(2t)-isoprostane levels showed a moderate negative correlation with birth weight and were higher in small co-twins of discordant pairs; tAOC was positively correlated with birth weight but no significant difference was found between co-twins. CONCLUSIONS: Oxidative stress levels in twins are mainly influenced by birth weight and weight discordance and suggest that evaluation of cord blood 15-F(2t)-isoprostane might be of clinical value as maker of pre- and perinatal distress in twinning. |
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Authors:
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Luisa Minghetti; Agnese Suppiej; Anita Greco; Malida Franzoi; Irene Pascoli; Vincenzo Zanardo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier Inc. |
Affiliation:
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Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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