Document Detail

Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis.
MedLine Citation:
PMID:  16283096     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of oxidative stress in patients with multiple sclerosis (MS) is poorly understood. OBJECTIVE: To investigate oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of MS. METHODS: Diene conjugate (DC) levels (a measure of lipid peroxidation), total antioxidative activity (AOA) and total antiradical activity (ARA) were measured in serum and peripheral blood leukocytes from 30 patients with benign relapsing remitting MS (BMS), 27 with secondary progressive MS (SPMS), 29 with primary progressive MS (PPMS), and 30 healthy controls. All MS patients were in a clinically stable phase. RESULTS: Serum DC levels were elevated in patients with BMS (p <0.05), SPMS (p <0.01) and PPMS (p <0.001). Serum total AOA and ARA were not different between MS patients and controls. Compared to controls, leukocyte DC levels were not different in each MS subgroup, but total ARA was elevated. There was a strong correlation, both in controls and MS patients, between leukocyte DC levels and leukocyte total ARA (p <0.0001) and leukocyte total AOA (p <0.0001). CONCLUSION: Oxidative stress occurs in progressive as well as benign MS. The finding that cells withstand oxidative stress, due to upregulated cellular antioxidant defence mechanisms, suggests that reactive oxygen species (ROS) formation in MS is not necessarily deleterious.
Marcus Koch; Geeta S M Ramsaransing; Alexander V Arutjunyan; Michael Stepanov; Albert Teelken; Dorothea J Heersema; Jacques De Keyser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-14
Journal Detail:
Title:  Journal of neurology     Volume:  253     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-11     Completed Date:  2007-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  483-7     Citation Subset:  IM    
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
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MeSH Terms
Antioxidants / metabolism
Disease Progression
Free Radical Scavengers / metabolism
Hydrogen Peroxide / blood
Interferons / therapeutic use
Leukocyte Count
Leukocytes / metabolism*
Lipid Peroxidation / physiology
Middle Aged
Multiple Sclerosis / blood*,  drug therapy
Oxidative Stress / physiology*
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 7722-84-1/Hydrogen Peroxide; 9008-11-1/Interferons

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