Document Detail

Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA).
MedLine Citation:
PMID:  17992715     Owner:  NLM     Status:  MEDLINE    
Our study examined if dietary long-chain polyunsaturated fatty acids (LCPUFA) have an impact on oxidative stress in preterm infants. Serum malonyldialdehyde (MDA), total peroxide concentrations, and total antioxidant capacity were determined at mean (standard deviation [SD]) 34.7 (10.9) days of life in 104 healthy preterm infants (gestational age, 32.6 [2.9] weeks; birthweight; 1605 [285] g) who were randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic) (group A, n = 50) or a LCPUFA-free formula with identical compositions for other nutrients (group B, n = 54). Clinical and anthropometric characteristics did not differ significantly between the two groups. Mean (SD) serum MDA levels did not differ significantly between groups A (0.23 [0.04] micromol/L) and B (0.22 [0.05] micromol/L). The concentrations of total peroxides were below the detection limits of the assay in 41 of 50 (82%) infants of group A and 43 of 54 (79%) infants of group B and not significantly different between the two infant groups. No difference was observed in serum total antioxidant capacity between groups A (340.0 [46.2] micromol/L) and B (354.7 [46.5] micromol/L). We concluded that supplementation of infant formulas with LCPUFA does not affect lipid peroxidation in healthy preterm infants.
Tania Siahanidou; Christina Lazaropoulou; Kelly Michalakakou; Ioannis Papassotiriou; Chrysa Bacoula; Helen Mandyla
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  24     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  475-9     Citation Subset:  IM    
Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Athens, Greece.
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MeSH Terms
Arachidonic Acid / administration & dosage*
Docosahexaenoic Acids / administration & dosage*
Infant Formula* / chemistry
Infant, Newborn
Infant, Premature / metabolism*
Lipid Peroxidation
Malondialdehyde / blood
Oxidative Stress / physiology*
Prospective Studies
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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