| Oxidative stress in preterm infants fed a formula containing long-chain polyunsaturated fatty acids (LCPUFA). | |
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MedLine Citation:
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PMID: 17992715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our study examined if dietary long-chain polyunsaturated fatty acids (LCPUFA) have an impact on oxidative stress in preterm infants. Serum malonyldialdehyde (MDA), total peroxide concentrations, and total antioxidant capacity were determined at mean (standard deviation [SD]) 34.7 (10.9) days of life in 104 healthy preterm infants (gestational age, 32.6 [2.9] weeks; birthweight; 1605 [285] g) who were randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic) (group A, n = 50) or a LCPUFA-free formula with identical compositions for other nutrients (group B, n = 54). Clinical and anthropometric characteristics did not differ significantly between the two groups. Mean (SD) serum MDA levels did not differ significantly between groups A (0.23 [0.04] micromol/L) and B (0.22 [0.05] micromol/L). The concentrations of total peroxides were below the detection limits of the assay in 41 of 50 (82%) infants of group A and 43 of 54 (79%) infants of group B and not significantly different between the two infant groups. No difference was observed in serum total antioxidant capacity between groups A (340.0 [46.2] micromol/L) and B (354.7 [46.5] micromol/L). We concluded that supplementation of infant formulas with LCPUFA does not affect lipid peroxidation in healthy preterm infants. |
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Authors:
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Tania Siahanidou; Christina Lazaropoulou; Kelly Michalakakou; Ioannis Papassotiriou; Chrysa Bacoula; Helen Mandyla |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of perinatology Volume: 24 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-11-08 Completed Date: 2007-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 475-9 Citation Subset: IM |
Affiliation:
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Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid
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administration & dosage* Docosahexaenoic Acids / administration & dosage* Female Humans Infant Formula* / chemistry Infant, Newborn Infant, Premature / metabolism* Lipid Peroxidation Male Malondialdehyde / blood Oxidative Stress / physiology* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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