Document Detail

Oxidative stress in non-small cell lung cancer: role of nicotinamide adenine dinucleotide phosphate oxidase and glutathione.
MedLine Citation:
PMID:  19308756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cigarette smoke is strongly associated with NSCLC, but the carcinogenesis of NSCLC is poorly understood. METHODS: To discover the role of oxidative stress and anti-oxidative defense in NSCLC, we measured NADPH oxidase (NOX) activity, myeloperoxidase activity, 8-OHdG, and glutathione content from lung specimens. These came from 32 patients: 22 NSCLC patients and ten controls without cancer. RESULTS: In NSCLC patients, NOX activity was significantly higher both in the malignant (p = 0.001) and non-malignant (p = 0.044) samples from NSCLC patients, than in the control specimens. Myeloperoxidase activity was lower (p = 0.001) and glutathione content (p = 0.009) higher in malignant tissue. No significant difference was observable in 8-OHdG content between patient groups. CONCLUSIONS: Increase in NOX activity in the malignant tissues was independent of smoking history and myeloperoxidase activity, suggesting its independent role in NSCLC pathogenesis.
Ilkka K Ilonen; Jari V R??s??nen; Eero I Sihvo; Aija Knuuttila; Kaisa M Salmenkivi; Markku O Ahotupa; Vuokko L Kinnula; Jarmo A Salo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  48     ISSN:  1651-226X     ISO Abbreviation:  Acta Oncol     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1054-61     Citation Subset:  IM    
Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Adenocarcinoma / enzymology*
Aged, 80 and over
Antioxidants / metabolism
Carcinoma, Non-Small-Cell Lung / enzymology*
Carcinoma, Squamous Cell / enzymology*
Case-Control Studies
Deoxyguanosine / analogs & derivatives,  metabolism
Glutathione / metabolism*
Lung Neoplasms / enzymology*
Middle Aged
NADPH Oxidase / metabolism*
Oxidative Stress*
Peroxidase / metabolism*
Smoking / adverse effects
Young Adult
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Antioxidants; 70-18-8/Glutathione; 961-07-9/Deoxyguanosine; EC; EC Oxidase

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