Document Detail

Oxidative stress in liver and red blood cells in acute lindane toxicity in rats.
MedLine Citation:
PMID:  19880658     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to determine the role and dynamics of oxidative and nitrosative stress, as well as superoxide dismutase (SOD) and catalase activity in the hepatocytes and erythrocytes in early phase of acute lindane intoxication. Male Wistar rats were divided into groups: control, dimethylsulfoxide and lindane-treated groups (L, 8 mg/kg, intraperitoneally). Animals were sacrificed 0.5 and 4 hours after treatment (L(0.5) and L(4) groups, respectively). Oxidative and nitrosative stress parameters and antioxidant enzymes were determined spectrophotometrically. Liver and plasma thiobarbituric acid reactive substances (TBARS) concentration were significantly increased 0.5 after lindane administration (p < .01), with subsequent additional rise within 4 hours (p < .01), while plasma nitrite + nitrate level was significantly higher only 4 hours after lindane treatment. Total liver SOD activity was significantly increased in L(4) group in comparison with control group (p < .01). In conclusion, oxidative and nitrosative stress play an important role in early phase of acute lindane hepatotoxicity. Antioxidant capacity of hepatocytes is partly increased, due to an adaptive increase in SOD activity.
T Radosavljevi?; D Mladenovi?; V Jakovljevi?; D Vucvi?; A Ras?-Markovi?; D Hrnci?; D Djuric; O Stanojlovi?
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  28     ISSN:  1477-0903     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  747-57     Citation Subset:  IM    
Department of Pathophysiology, School of Medicine, University of Belgrade, Dr Suboti?a 9, 11000 Belgrade, Serbia.
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MeSH Terms
Drug-Induced Liver Injury / enzymology
Erythrocytes / drug effects*,  enzymology,  metabolism*
Insecticides / toxicity*
Lindane / toxicity*
Lipid Peroxidation / drug effects
Liver / drug effects*,  enzymology,  metabolism*
Nitrates / blood
Nitrites / blood
Oxidative Stress / drug effects*,  physiology
Rats, Wistar
Reactive Nitrogen Species / metabolism
Superoxide Dismutase / metabolism
Superoxides / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Insecticides; 0/Nitrates; 0/Nitrites; 0/Reactive Nitrogen Species; 0/Thiobarbituric Acid Reactive Substances; 11062-77-4/Superoxides; 58-89-9/Lindane; EC Dismutase

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