Document Detail

Oxidative stress in erythrocytes from premature and full-term infants during their first 72 h of life.
MedLine Citation:
PMID:  12688427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to evaluate the extent of lipid peroxidation and the response of the enzymatic and non-enzymatic antioxidant defence system in erythrocytes from full-term and premature infants at birth, after 3 and after 72 h of life. STUDY DESIGN: Twenty infants were selected and divided in two groups according to their gestational age. Blood samples were taken at birth, at 3 and at 72 h of life, erythrocytes were isolated and the following parameters were measured: fatty-acid profile, coenzyme Q, alpha-tocopherol, hydroperoxides and the activity of the antioxidant enzymes catalase, superoxide dismutase (SOD) and cytosolic glutathione peroxidase (cGPx). RESULTS: For the three studied periods, several differences between full-term and premature infants were found. Premature children showed a higher concentration of hydroperoxides, a lower level of alpha-tocopherol and lower SOD and cGPx activity (except for cGPx at birth). Moreover, n-3 polyunsaturated fatty-acids percentages (essential for good neonatal development) were higher in full term children throughout all the study. CONCLUSION: Results suggest a strong imbalance between oxidants and antioxidants in premature infants during their first 72 h of life, a situation which could lead to several pathologies. Therefore, further research is needed, including possible nutritional intervention (with antioxidant therapy, supplementation of essential fatty acids and other dietary constituents) before and after birth.
Julio J Ochoa; M Carmen Ramirez-Tortosa; José L Quiles; Narcisa Palomino; Rafael Robles; José Mataix; Jesús R Huertas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  37     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Institute of Nutrition and Food Technology (INYTA), Granada, Spain.
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MeSH Terms
Antioxidants / pharmacology*
Apgar Score
Body Weight
Catalase / blood
Cytosol / metabolism
Erythrocytes / metabolism*
Fatty Acids / metabolism
Gestational Age
Glutathione Peroxidase / blood
Hydrogen Peroxide / pharmacology
Infant, Newborn
Infant, Premature
Oxidative Stress*
Oxygen / metabolism
Superoxide Dismutase / blood
Time Factors
Ubiquinone / blood
alpha-Tocopherol / blood,  metabolism
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 1339-63-5/Ubiquinone; 59-02-9/alpha-Tocopherol; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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