| Oxidative stress in childhood obesity. | |
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MedLine Citation:
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PMID: 15379416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure products of free radical damage in childhood obesity. METHODS: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. RESULTS: D-Roms levels were higher in the obese children than in the non-obese group (33.3+/-10.1 mg% of H2O2 vs 22.8+/-2.8 mg% of H2O2; p <0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6+/-3.1 mg% of H2O2 vs 27.8+/-3.2 mg% of H2O2; p <0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p <0.001) and serum total cholesterol (p <0.001), with the total variance explained being 82%. CONCLUSION: Our study demonstrates for the first time that there was increased D-Roms levels in obese children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity. |
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Authors:
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Mehmet Emre Atabek; Husamettin Vatansev; Ibrahim Erkul |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 17 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-21 Completed Date: 2005-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 1063-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey. meatabek@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Glucose Blood Pressure Child Female Free Radicals / blood* Humans Hyperlipidemias / blood*, complications Hypertension / blood*, complications Male Obesity / blood*, complications Oxidative Stress / physiology* Reference Values Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Free Radicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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