Document Detail

Oxidative stress in childhood obesity.
MedLine Citation:
PMID:  15379416     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure products of free radical damage in childhood obesity. METHODS: Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. RESULTS: D-Roms levels were higher in the obese children than in the non-obese group (33.3+/-10.1 mg% of H2O2 vs 22.8+/-2.8 mg% of H2O2; p <0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6+/-3.1 mg% of H2O2 vs 27.8+/-3.2 mg% of H2O2; p <0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p <0.001) and serum total cholesterol (p <0.001), with the total variance explained being 82%. CONCLUSION: Our study demonstrates for the first time that there was increased D-Roms levels in obese children and adolescents and suggests that increased systolic blood pressure associated with hyperlipidemia may independently contribute to increased oxidative stress in childhood obesity.
Mehmet Emre Atabek; Husamettin Vatansev; Ibrahim Erkul
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  17     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-21     Completed Date:  2005-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1063-8     Citation Subset:  IM    
Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey.
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MeSH Terms
Blood Glucose
Blood Pressure
Free Radicals / blood*
Hyperlipidemias / blood*,  complications
Hypertension / blood*,  complications
Obesity / blood*,  complications
Oxidative Stress / physiology*
Reference Values
Statistics, Nonparametric
Reg. No./Substance:
0/Blood Glucose; 0/Free Radicals

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