Document Detail

Oxidative stress in Lactococcus lactis.
MedLine Citation:
PMID:  15011138     Owner:  NLM     Status:  MEDLINE    
Lactococcus lactis, the most extensively characterized lactic acid bacterium, is a mesophilic- and microaerophilic-fermenting microorganism widely used for the production of fermented food products. During industrial processes, L. lactis is often exposed to multiple environmental stresses (low and high temperature, low pH, high osmotic pressure, nutrient starvation and oxidation) that can cause loss or reduction of bacterial viability, reproducibility, as well as organoleptic and/or fermentative qualities. Among these stress factors, oxidation can be considered one of the most deleterious to the cell, causing cellular damage at both molecular and metabolic levels. During the last two decades, considerable efforts have been made to improve our knowledge of oxidative stress in L. lactis. Many genes involved with both oxidative stress resistance and control mechanisms have been identified; functionally they seem to overlap. The finding of new genes, and a better understanding of the molecular mechanisms of stress resistance in L. lactis and other lactic acid bacterium, will lead to the construction and isolation of stress-resistant strains. Such strains could be exploited for both traditional and probiotic uses.
Anderson Miyoshi; Tatiana Rochat; Jean-Jacques Gratadoux; Yves Le Loir; Sérgio Costa Oliveira; Philippe Langella; Vasco Azevedo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2003-12-30
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  2     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2003  
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-06-07     Revised Date:  2007-05-02    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  348-59     Citation Subset:  IM    
Department of General Biology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
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MeSH Terms
Cell Survival / genetics
Genes, Bacterial / genetics
Lactococcus lactis / genetics,  metabolism*
Multienzyme Complexes / metabolism
NADH, NADPH Oxidoreductases / metabolism
Oxidative Stress / genetics,  physiology*
Peroxidases / metabolism
Rec A Recombinases / metabolism
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Multienzyme Complexes; EC 1.11.1.-/Peroxidases; EC peroxidase; EC Dismutase; EC 1.6.-/NADH oxidase; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 2.7.7.-/Rec A Recombinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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