Document Detail


Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension.
MedLine Citation:
PMID:  25085432     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and progression of systemic sclerosis-associated pulmonary arterial hypertension remain largely unknown. Here we shows for the first time that an increase of NADPH-derived reactive oxygen species production induced by sera from systemic sclerosis patients with pulmonary arterial hypertension drives collagen type I promoter activity in primary human pulmonary artery smooth muscle cells, suggesting that antioxidant-based therapies should be considered in the treatment of systemic sclerosis-associated vascular diseases.
Authors:
Francesco Boin; Gian Erre; Anna Posadino; Annalisa Cossu; Roberta Giordo; Gaia Spinetti; Giuseppe Passiu; Costanza Emanueli; Gianfranco Pintus
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-1
Journal Detail:
Title:  Orphanet journal of rare diseases     Volume:  9     ISSN:  1750-1172     ISO Abbreviation:  Orphanet J Rare Dis     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266602     Medline TA:  Orphanet J Rare Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  123     Citation Subset:  -    
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