Document Detail

Oxidative stress and delta-ALA-D activity in chronic renal failure patients.
MedLine Citation:
PMID:  17383846     Owner:  NLM     Status:  MEDLINE    
In this paper, we studied the influence of uremia and hemodialysis on oxidative parameters and delta-aminolevulinic acid dehydratase (delta-ALA-D) activity in control subjects, patients with chronic renal failure (CRF) on hemodialysis treatment (HD) and in patients not undergoing hemodialysis (ND). An increased lipid peroxidation was observed in the serum of HD and ND patients, as measured by the MDA serum levels. However, the level of MDA from erythrocytes was only elevated in HD patients. Blood catalase activity was increased in HD and ND groups. This study also showed a decreased activity of blood delta-aminolevulinic acid dehydratase (delta-ALA-D) in both groups of patients. This study demonstrated a positive correlation between ALA-D activity and hemoglobin, suggesting that inhibition of this enzyme might enhance anemia in CRF. A negative correlation was found between the alteration in delta-ALA-D activity and oxidative stress, which may indicate that the inhibition of ALA-D can be used as an index of oxidative stress.
Adriane C da Silva; João B T Rocha; André L B Morsch; Rafael F Zanin; Rosilene Kaizer; Paula Acosta Maldonado; Luís C Arantes; Luís A Silva; Vera M Morsch; Maria R C Schetinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-21
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  61     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:    2007 Feb-Apr
Date Detail:
Created Date:  2007-04-17     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900 Santa Maria, RS, Brazil.
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MeSH Terms
Aged, 80 and over
Catalase / blood,  metabolism
Kidney Failure, Chronic / physiopathology*
Lipid Peroxidation
Middle Aged
Oxidative Stress*
Porphobilinogen Synthase / blood,  metabolism*
Renal Dialysis*
Uremia / physiopathology*
Reg. No./Substance:
0/Hemoglobins; EC; EC Synthase

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