| Oxidative stress causes heart failure with impaired mitochondrial respiration. | |
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MedLine Citation:
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PMID: 16959785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elderly people insidiously manifest the symptoms of heart failure, such as dyspnea and/or physical disabilities in an age-dependent manner. Although previous studies suggested that oxidative stress plays a pathological role in the development of heart failure, no direct evidence has been documented so far. In order to investigate the pathological significance of oxidative stress in the heart, we generated heart/muscle-specific manganese superoxide dismutase-deficient mice. The mutant mice developed progressive congestive heart failure with specific molecular defects in mitochondrial respiration. In this paper, we showed for the first time that the oxidative stress caused specific morphological changes of mitochondria, excess formation of superoxide (O(2)(*)(-)), reduction of ATP, and transcriptional alterations of genes associated with heart failure in respect to cardiac contractility. Accordingly, administration of a superoxide dismutase mimetic significantly ameliorated the symptoms. These results implied that O(2)(*)(-) generated in mitochondria played a pivotal role in the development and progression of heart failure. We here present a bona fide model for human cardiac failure with oxidative stress valuable for therapeutic interventions. |
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Authors:
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Hidetoshi Nojiri; Takahiko Shimizu; Masabumi Funakoshi; Osamu Yamaguchi; Heying Zhou; Satoru Kawakami; Yutaka Ohta; Manabu Sami; Toshiaki Tachibana; Hiroshi Ishikawa; Hisashi Kurosawa; Ronald C Kahn; Kinya Otsu; Takuji Shirasawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-06 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 281 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2006-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 33789-801 Citation Subset: IM |
Affiliation:
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Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Disease Progression Gene Expression Regulation Heart Diseases / genetics, metabolism*, pathology* Lipid Peroxidation Mice Mice, Knockout Microscopy, Electron, Transmission Mitochondria, Heart / metabolism* Muscle, Skeletal / cytology, metabolism Oxidative Stress* Reactive Oxygen Species / metabolism Superoxide Dismutase / deficiency, genetics, metabolism Transcription, Genetic / genetics |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; EC 1.15.1.1/Superoxide Dismutase; EC 1.15.1.1/superoxide dismutase 2 |
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