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Oxidative stress is associated with migraine and migraine-related metabolic risk in females.
MedLine Citation:
PMID:  21518147     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and purpose:  Oxidative stress is discussed to be implicated in the pathophysiology of migraine. However, data are in part controversial and the possible underlying mechanisms remain elusive to date. The aim of this study was to investigate the oxidative stress status of female patients with migraine and its implications on migraine-related metabolic alterations. Methods:  Oxidative stress markers malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), carbonylated proteins, parameters of associated nitric oxide stress, inflammation, lipid- and glucose-metabolism were determined in the interictal phase in female patients with migraine and controls. Results:  We found significantly increased HNE levels in female migraineurs compared with controls. Logistic regression analyses of HNE revealed an odds ratio for migraine of 4.55. HNE showed significant correlations with the nitric oxide pathway, the insulin- and the lipid-metabolism. Conclusions:  We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target.
Authors:
C Bernecker; C Ragginer; G Fauler; R Horejsi; R Möller; S Zelzer; A Lechner; M Wallner-Blazek; S Weiss; F Fazekas; B Bahadori; M Truschnig-Wilders; H-J Gruber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-23
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  -     ISSN:  1468-1331     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
Affiliation:
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz Center for Physiological Medicine, Medical University Graz, Graz Department of Neurology, Medical University Graz, Graz Department of Internal Medicine 2; State Clinic St. Poelten, St. Poelten, Austria.
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