| Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 18568574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Reperfusion of ischemic myocardium evokes rapid release of free radicals in experimental models. The aim of the study was to investigate the oxidative stress and antioxidative defense during first minutes after reopening of the infarct related artery in patients treated for acute myocardial infarction. The study group consisted of 15 patients with first ST elevation myocardial infarction (STEMI) due to left anterior descending artery occlusion. The control group included ten patients with stable ischemic heart disease (IHD). Blood samples from coronary sinus were drawn before, immediately after and about 15 min after angioplasty. Activity of superoxide dysmutase (SOD), concentration of glutathione as well as the concentrations of lipid peroxides, malodialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) were measured. There was significantly higher concentration of MDA and HNE and higher SOD activity in STEMI patients before the reperfusion, as compared to the stable IHD group. After the reperfusion concentration of HNE in erythrocytes from STEMI patients was higher than in IHD group. At the same time the activity of SOD significantly decreased in patients with impaired tissue perfusion (myocardial blush grade <2). In conclusion, there is a slightly higher concentration of oxidative stress parameters in patients with STEMI. Diminished antioxidative defense after reperfusion is associated with impaired myocardial perfusion. |
| | |
Authors:
|
K Kaminski; T Bonda; I Wojtkowska; S Dobrzycki; P Kralisz; K Nowak; P Prokopczuk; E Skrzydlewska; M Kozuch; W J Musial |
Related Documents
:
|
12813004 - Endocannabinoids protect the rat isolated heart against ischaemia. 7942434 - Myocardial salvage: its assessment and prediction by the analysis of serial myocardial ... 19665464 - Chemokine ccl5/rantes inhibition reduces myocardial reperfusion injury in atherosclerot... 7484754 - Effect of the hydrophilic alpha-tocopherol analog mdl 74,405 on detection of hydroxyl r... 18208664 - Effects of spironolactone on electrical and structural remodeling of atrium in congesti... 20855374 - Idiopathic ventricular arrhythmias originating from the left ventricular summit: anatom... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acute cardiac care Volume: 10 ISSN: 1748-2941 ISO Abbreviation: Acute Card Care Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-06-23 Completed Date: 2008-11-04 Revised Date: 2009-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 101276603 Medline TA: Acute Card Care Country: Sweden |
Other Details:
|
Languages: eng Pagination: 121-6 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. fizklin@mp.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aldehydes / blood Antioxidants / metabolism* Biological Markers / blood* Coronary Angiography Electrocardiography Follow-Up Studies Glutathione / blood Humans Lipid Peroxides / blood Malondialdehyde / blood Middle Aged Myocardial Infarction / blood*, diagnosis, therapy Myocardial Reperfusion / methods* Oxidative Stress* Prognosis Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
|
0/Aldehydes; 0/Antioxidants; 0/Biological Markers; 0/Lipid Peroxides; 29343-52-0/4-hydroxy-2-nonenal; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: First use of a novel plug-and-play percutaneous circulatory assist device for high-risk coronary ang...
Next Document: Trichotillomania and Pathologic Skin Picking: clinical comparison with an examination of comorbidity...